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Table 1 Patients demographic and clinicopathological characteristics based on age group

From: Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study

Variable

Category

Total (n = 396)

Age group

p value

≤ 50 years (n = 156)

> 50 years (n = 240)

Sex

Female

184 (46.5)

72 (46.2)

112 (46.7)

0.920

Male

212 (53.5)

84 (53.8)

128 (53.3)

 

Symptom

Rectal bleeding

186 (47)

74 (47.4)

112 (46.7)

0.130

Change in bowel habit

78 (19.7)

31 (19.9)

47 (19.6)

 

Abdominal pain

65 (16.4)

24 (15.4)

41 (17.1)

 

Melena

38 (9.6)

10 (6.4)

28 (11.7)

 

Obstruction

16 (4)

8 (5.1)

8 (3.3)

 

Others

13 (3.3)

9 (5.8)

4 (1.7)

 

BMI

< 25

197 (49.7)

78 (50)

119 (49.6)

0.928

25–29.9

113 (28.5)

43 (27.6)

70 (29.2)

 

> 29.9

86 (21.7)

35 (22.4)

51 (21.3)

 

Family history of cancer

Positive

45 (11.4)

18 (11.5)

27 (11.3)

0.930

Relativeness

First order

37 (9.3)

16 (10.3)

21 (8.8)

0.919

Second order

7 (1.8)

3 (1.9)

4 (1.7)

 

Family history of CRC

CRC

29 (7.3)

14 (9)

15 (6.3)

0.371

Others

15 (3.8)

4 (2.6)

11 (4.6)

 

Tumor site

Colon

160 (40.4)

52 (33.3)

108 (45)

0.021

Rectum

236 (59.6)

104 (66.7)

132 (55)

 

TNM stage

I

42 (10.6)

18 (11.5)

24 (10)

0.266

II

161 (40.7)

55 (35.3)

106 (44.2)

 

III

140 (35.4)

63 (40.4)

77 (32.1)

 

IV

53 (13.4)

20 (12.8)

33 (13.8)

 

Tumor grade

Well

187 (47.2)

56 (35.9)

131 (54.6)

< 0.001

Moderate

166 (41.9)

77 (49.4)

89 (37.1)

 

Poor

43 (10.9)

23 (14.7)

20 (8.3)

 

Smoker

 

28 (41.9)

7 (4.5)

21 (8.8)

0.106

Hypertension

 

37 (9.3)

4 (2.6)

33 (13.8)

< 0.001

Diabetes mellitus

 

26 (6.6)

3 (1.9)

23 (9.6)

0.003

Coronary heart disease

 

22 (5.6)

2 (1.3)

20 (22)

0.003

Other diseases

 

12 (3)

2 (1.3)

10 (4.2)

0.102

CEA**

< 5

271 (68.4)

102 (65.4)

169 (70.4)

0.292

≥ 5

125 (31.6)

54 (34.6)

71 (26.9)

 

Symptom duration

 

6 (4–12)

6 (4–12)

6 (3.6–10)

0.102

  1. Data are presented as frequency (percent) or median (IQR) wherever it was needed
  2. TNM tumor node metastasis, BMI body mass index, CEA carcinoembryonic antigen, **the imputed data are represented