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Table 3 GFR as an indicator for renal toxicity

From: Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation

Number of patients

Number of cycles planned

Number of cycles completed

Number of GFR evaluations

Decrement in GFR

Dose modification of carboplatin

Nephrotoxicity

Dialysis

Transplant-related mortality

15

21

21

54

No

No

Not more than grade 1

No

No

1 (A)

Single - 1

1

Baseline 24hrCrCl, then 2 GFR

No

No

Grade 5

Yes

Yes

1 (B)

Tandem - 3

2

4

No

No

Grade 5

Yes

Yes

1 (C)

Single – 1

1

3

Yes

Dose 3 omitted

Grade 1

No

No

1 (D)

Single – 1

1

3

Yes

Dose 3 omitted

Grade 2

No

No

1 (E)

Tandem - 3

2

4

Yes

Cycle 2, dose 2 decreased 50%; Cycle 3 omitted

Grade 4

Yes

No

  1. 24hrCrCl 24-h creatinine clearance, GFR glomerular filtration rate