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Table 2 Clinico-pathological characteristics in relation to IHC expression of CD68 and CD163

From: Clinico-pathological significance of immunohistochemically marked tumor-associated macrophage in classic Hodgkin lymphoma

   CD68 P value CD163 P value
1 2 3 1 2 3
Age category < 45 years 31% 30% 11% 0.5 29% 31% 12% 0.05*
≥ 45 years 10% 11% 7% 8% 9% 11%
Gender Male 10% 19% 8% 0.5 9% 14% 14% 0.02*
Female 31% 22% 10% 28% 26% 9%
HB category < 10.5 g/dl 17% 13% 6% 0.6 16% 30% 10% 0.17
≥ 10.5 g/dl 24% 28% 12% 21% 27% 13%
WBCs category < 15 × 109/l 35% 34% 16% 0.8 30% 35% 20% 0.7
≥ 15× 109/l 6% 7% 2% 7% 5% 3%
Albumin level < 4 g/dl 16% 14% 5% 0.9 15% 10% 10% 0.03*
≥ 4 g/dl 24% 21% 7%
20% 27% 5%
HCV virology Negative 35% 34% 14% 0.4 32% 34% 20% 0.9
Positive 6% 7% 1% 5% 6% 3%
B symptoms Absent 23% 15% 8% 0.2 23% 16% 7% 0.04*
Present 18% 16% 10% 14% 24% 16%
Bulky disease No 40% 37% 12% 0.005* 36% 37% 16% 0.005*
Yes 1% 4% 6% 1% 3% 7%
Histopathology subtype LR 4% 7% 1% 0.5 5% 4% 3% 0.86
MC 21% 18% 7% 16% 21% 9%
NS 16% 16% 10% 16% 15% 11%
Extra nodal disease No 34% 25% 14% 0.07 29% 27% 17% 0.55
Yes 7% 16% 4% 8% 13% 6%
Stage Limited 14% 4% 3% 0.02* 13% 6% 2% 0.02*
Advanced 27% 37% 15% 24% 34% 21%
IPS < 3 30% 23% 7% 0.04* 25% 27% 8% 0.02*
≥ 3 11% 18% 11% 12% 13% 15%
ORR CR/PR 38% 24% 11% 0.001* 34% 28% 11% 0.001*
NO CR/PR 3% 17% 7% 3% 12% 12%
  1. HB hemoglobin, WBC white blood cell count, HCV Hepatitis C virus, MC mixed cellularity, NS nodular sclerosis, LR lymphocyte rich, IPS International Prognostic score, ORR overall response rate, CR complete response, PR partial response