Management and outcome of pediatric metastatic Wilms’ tumor at the National Cancer Institute, Egypt

Elayadi, Moatasem; Magdy, Sarah; Khalil, Ehab; Zekri, Wael

doi:10.1186/s43046-020-00031-7

Journal of the Egyptian National Cancer Institute

Table 4 Details of management, response, and outcome of study patients

From: Management and outcome of pediatric metastatic Wilms’ tumor at the National Cancer Institute, Egypt

Case NO.	Site of Mets		Local Stage		Initial Management		Response (W6)		Surgical Comp.	Pathology			RT		Adjuvant CTH	Events			0utcome
Case NO.	Lung	Liver		Cause	Nephrectomy	CTH	Local	Met. Site	Surgical Comp.	SM	LNs	Others	Local	Met. site	Adjuvant CTH	Lung	Local	Sepsis	0utcome
1	√	ˣ	3	Biopsy LNs		√	↓	SIR	ˣ	-VE	+VE				DD4A	®			Died
2	√	√	3	Biopsy		√	↓	↓	ˣ	-VE	Not assessed				Reg M	®			FU
3	√	ˣ	3	Biopsy IVC		√	↓	RCR	ˣ	-VE	-VE				DD4A	®			FU
4	√	ˣ	3	SM	√		Free	RCR	√	+VE	-VE				DD4A			√	Died
5	√	ˣ	3	Residual IVC	√		Free	SIR	ˣ	-VE	-VE				Reg M	P			Died
6	√	ˣ	3	Biopsy		√	↓	SIR	NO Nephrectomy						DD4A	P	P		Died
7	√	ˣ	1		√		Free	SIR	ˣ	-VE	-VE				Reg M	P			Died
8	√	√	3	Biopsy		√	↓	Free	ˣ	-VE	-VE				DD4A		®		Died
9	√	ˣ	3	Biopsy LNs		√	↓	SIR	√	-VE	+VE				Reg M	p	®		Died
10	√	ˣ	3	CTH		√	↓	SIR	ˣ	-VE	Not assessed	Blastem. pred.			DD4A	®	®		Died
11	√	ˣ	3	Biopsy		√	Stationary	SIR	Palliative Nephrectomy			Blastema. Pred.			ICE	P	P		Died
12	√	ˣ	3	T. Rupture LNs	√		Free	SIR	√	-VE	+VE				Reg M	P	®		Died
13	√	√	1		√		Free	↓	ˣ	-VE	-VE				Reg M			√	Died
14	√	ˣ	3	Biopsy		√	↓	SIR	ˣ	-VE	Not assessed		√	√	DD4A				FU
15	√	ˣ	3	Biopsy LNs		√	↓	SIR	ˣ	-VE	+VE		√	√	Reg M				FU
16	√	ˣ	3	Biopsy		√	↓	RCR	ˣ	-VE	Not assessed		√	ˣ	DD4A				FU
17	√	ˣ	3	Biopsy		√	↓	SIR	ˣ	-VE	-VE		√	√	Reg M				FU
18	√	ˣ	3	Biopsy		√	↓	SIR	ˣ	-VE	-VE		√	√	Reg M				FU
19	√	ˣ	3	Biopsy IVC		√	↓	SIR	ˣ	-VE	-VE		√	√	Reg M				FU
20	√	ˣ	3	Residual	√		Free	RCR	ˣ	-VE	Not assessed		√	ˣ	DD4A				FU
21	√	ˣ	3	Residual	√		Free	RCR	ˣ	+VE	Not assessed		√	√	DD4A				FU
22	√	ˣ	3	LNs	√		Free	SIR	√	-VE	+VE		√	√	Reg M				FU
23	√	ˣ	3	Residual	√		Free	RCR	ˣ	+VE	Not assessed		√	ˣ	DD4A				FU
24	√	ˣ	3	Biopsy LNs		√	Fee	RCR	ˣ	-VE	+VE		√	ˣ	DD4A				FU

® relapse, P progression, ↓ regressive, LNs lymph nodes, IVC inferior vena cava, SM surgical margin, CTH chemotherapy, RT radiotherapy, FU follow-up, RCR rapid complete response, SIR slow incomplete response, Reg M 5-drug regimen, DD4A 3-drug regimen, ICE ifosfamide, carboplatin, and etoposide

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