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Table 2 Genotype and allele frequencies of NME1 gene EcoR1 (rs34214448) and KISS1 gene 9 del T (rs5780218) SNPs in breast cancer patients and controls

From: Association of polymorphisms in metastasis suppressor genes NME1 and KISS1 with breast cancer development and metastasis

 

Breast cancer (n = 75)

Control (n = 37)

All (n = 112)

P value

NME1 gene EcoR1 (rs34214448)

Genotype

 G/G

26 (34.7%) *

35 (94.6%) *

61 (54%)

< 0.0005 (PMC)

 G/T

41 (54.7%) *

2 (5.4%) *

43 (38%)

 

 T/T

8 (10.7%) *

0 (0%) *

8 (7%)

 

Allele

 G

93 (62%) *

72 (97%) *

165 (74%)

< 0.0005

 T

57 (38%) *

2 (3%) *

59 (26%)

 

KISS1 gene 9 del T (rs5780218)

Genotype

 A/A

9 (12%)

11 (29.7%)

20 (18%)

0.068

 A/-

55 (73.3%)

21 (56.8%)

76 (68%)

 

 -/-

11 (14.7%)

5 (13.5%)

16 (14%)

 

Allele

 A

73 (49%)

43 (58%)

116 (52%)

0.183

 -

77 (51%)

31 (42%)

108 (48%)

 
  1. Data are presented as count (percent). P value by chi-square test
  2. (*)Indicates significant difference between the two groups
  3. n number, P probability, PMCP (Monte Carlo)