Table 3 Logistic regression analysis of the association between NME1 gene EcoR1 (rs34214448) and KISS1 gene 9 del T (rs5780218) SNPs and breast cancer risk
SNP | Model | Genotype | Control (n = 37) | Breast cancer (n = 75) | OR (95% CI) | P value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
NME1 gene EcoR1 (rs34214448) | ||||||||
Co-dominant | G/G G/T T/T | 35 (94.6%) 2 (5.4%) 0 (0%) | 26 (34.7%) 41 (54.7%) 8 (10.7%) | R 27.60 (6.11–124.59) NA (0.00–NA) | < 0.0001 | 105.4 | 113.6 | |
Dominant | G/G G/T-T/T | 35 (94.6%) 2 (5.4%) | 26 (34.7%) 49 (65.3%) | R 32.98 (7.35–148.08) | < 0.0001 | 104.1 | 109.5 | |
Recessive | G/G-G/T T/T | 37 (100%) 0 (0%) | 67 (89.3%) 8 (10.7%) | R NA (0.00–NA) | 0.0096 | 139.4 | 144.8 | |
Over-dominant | G/G-T/T G/T | 35 (94.6%) 2 (5.4%) | 34 (45.3%) 41 (54.7%) | R 21.10 (4.73–94.16) | < 0.0001 | 115.8 | 121.3 | |
Log-additive | – | – | – | 28.02 (6.29–124.91) | < 0.0001 | 103.4 | 108.9 | |
KISS1 gene 9delT (rs5780218) | ||||||||
Co-dominant | A/A A/- -/- | 11 (29.7%) 21 (56.8%) 5 (13.5%) | 9 (12%) 55 (73.3%) 11 (14.7%) | R 3.2 (1.16-8.83) 2.69 (0.68–10.65) | 0.077 | 143 | 151.2 | |
Dominant | A/A A/-,-/- | 11 (29.7%) 26 (70.3%) | 9 (12%) 66 (88%) | R 3.1 (1.15–8.36) | 0.025 | 141.1 | 146.5 | |
Recessive | A/A- A/- -/- | 32 (86.5%) 5 (13.5%) | 64 (85.3%) 11 (14.7%) | R 1.1 (0.35–3.44) | 0.87 | 146.1 | 151.5 | |
Over-dominant | A/A, -/- A/- | 16 (43.2%) 21 (56.8%) | 20 (26.7%) 55 (73.3%) | R 2.1 (0.92–4.79) | 0.08 | 143.1 | 148.5 | |
Log-additive | – | – | – | 1.83 (0.89–3.77) | 0.095 | 143.3 | 148.8 | |