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Table 1 Summary of the demographics and clinical data of previously reported cases of bone marrow metastasis from colorectal cancer

From: Metastatic colorectal carcinoma initially diagnosed by bone marrow biopsy: a case report and literature review

Article

Age/sex

Presentation pattern

Peripheral blood count

Primary tumor site

Other metastases

Treatment

Survival

Yoshioka et al. [9]

62/M

Primary

DIC

Rectum (diagnosed by autopsy)

N/A

N/A

Died after 13 days

Sema et al. [10]

61/M

N/A

DIC

Sigmoid

No

Supportive

Died after 2 weeks

Lee et al. [11]

67/M

Primary

Anemia/thrombocytopenia

Hepatic flexure

Bone

FOLFOX

Alive 18 weeks after diagnosis

Huang et al. [12]

79/M

Primary

DIC

Rectum

N/A

5FU + leucovorin

Died after 83 days

Pleyer et al. [13]

48/M

Primary

Thrombocytopenia

N/A

Peritoneal/pleural/pericardial effusion/mediastinal lymphadenopathy

FOLFOX + bevacizumab (surgery for the primary)

Died after 5 cycles of chemotherapy

Misawa et al. [14]

51/M

Primary

DIC

Ascending colon

Bone

No

Died after 25 days

Wang et al. [15]

37/M

Primary

Anemia/thrombocytopenia

Sigmoid

Bone

FOLFOX + cetuximab

Died after 3 months

Isozaki et al. [16]

45/M

Primary

DIC

Descending colon

Lymph nodes

mFOLFOX

N/A

Song and Dwyre [17]

70/M

Primary

Anemia

Rectum

Bone

N/A

N/A

Orgel et al. [18]

65/F

Primary

MAHA

Sigmoid

Hepatic

FOLFOX + cetuximab

Died after 7 months

Naito et al. [19]

61/M

Primary

DIC

Transverse colon

Bone/lymphadenopathy

XELOX + bevacizumab

Resolution after 4 cycles of chemotherapy + resection was considered

Nakashima et al. [20]

65/M

Primary

DIC

Rectum

Bone

mFOLFOX + bevacizumab + surgery

Died 128 POD

Shah et al. [8]

58/M

Primary

DIC

Cecum

Hepatic/mediastinal lymphadenopathy

mFOLFOX + FOLFIRI + bevacizumab

Died after 6 months

Van Banderin et al. [21]

65/F

Primary

DIC

Sigmoid

Bone

XELOX

Died after 8 months

Lim et al. [5]

74/F

Recurrent

Anemia/thrombocytopenia

History of right hemicolectomy

No

No

10 days after diagnosis

Assi et al. [6]

 1st case

75/M

Recurrent

Anemia/leucopenia

Rectum

No

FOLFOX + bevacizumab

Alive after 6 months

 2nd case

56/M

Primary

Anemia/thrombocytopenia

Rectosigmoid

Bone

FOLFOX

Died after 6 months

3rd case

55/M

Primary

Anemia/thrombocytopenia

Ascending colon

Bone

FOLFOX

Died after 4 months

Hanamura et al. [22]

60/M

Primary

DIC

Sigmoid

Bone

mFOLFOX + CapeOx + irinotecan + pantumumab

Died after 10 months

Takeyama et al. [23]

65/M

Recurrent

Leucopenia/thrombocytopenia

Hx of rectal resection

Bone/lung

mFOLFOX

Died 263 days from meningeal metastasis

Zeeneldin et al. [24]

42/M

Primary

Anemia/thrombocytopenia

Rectum

Bone/lung/lymphadenopathy

XELOX

Died after 6 months

  1. DIC disseminated intravascular coagulopathy, MAHA microangiopathic hemolytic anemia, N/A not available, POD postoperative day