Table 4 Association of telomere length, DAXX, ATRX expression, and clinicopathological parameters
From: Impact of DAXX and ATRX expression on telomere length and prognosis of breast cancer patients
Variable | Telomere length, n(%) | DAXX, n(%) | ATRX, n(%) | |||
|---|---|---|---|---|---|---|
Short | Long | Low | High | Low | High | |
Age | ||||||
< 40 years | 58(66) | 30(34) | 28(32) | 60(69) | 50(57) | 38(43) |
≥ 40 years | 98(74) | 34(26) | 54(41) | 78(59) | 52(39) | 80(61) |
P | 0.346 | 0.334 | 0.073 | |||
Tumor size # | ||||||
n | 156 | 64 | 82 | 138 | 102 | 118 |
Mean ± SD | 4.51 ± 2.24 | 3.38 ± 1.26 | 4.41 ± 1.92 | 4.04 ± 2.15 | 3.86 ± 1.12 | 4.46 ± 2.61 |
P | 0.003* | 0.201 | 0.056 | |||
Tumor grade | ||||||
GI | 9(30) | 21(70) | 10(33) | 20(67) | 12(40) | 18(60) |
GII | 116(89) | 14(11) | 66(51) | 64(49) | 71(55) | 59(45) |
GIII | 31(52) | 29(48) | 6(10) | 54(90) | 19(32) | 41(68) |
P | 0.011* | 0.015* | 0.032* | |||
Necrosis | ||||||
Absent | 54(47) | 60(53) | 26(23) | 88(77) | 52(46) | 62(54) |
Present | 102(96) | 4(4) | 56(53) | 50(47) | 50(47) | 56(53) |
P | 0.004* | 0.001* | 0.887 | |||
TILs | ||||||
Focal | 4(6) | 60(94) | 16(25) | 48(75) | 34(53) | 30(47) |
LPBC | 152(97) | 4(3) | 66(42) | 90(58) | 68(44) | 88(56) |
P | 0.003* | 0.88 | 0.362 | |||
VI | ||||||
Absent | 20(24) | 62(76) | 16(20) | 66(80%) | 38(46) | 54(54) |
Present | 136(99) | 2(1) | 66(48) | 72(52) | 64(46) | 64(54) |
P | 0.001* | 0.003* | 0.997 | |||
LN metastasis | ||||||
N0 | 26(29) | 64(29) | 22(24) | 68(76) | 44(49) | 46(21) |
N1 | 30(75) | 10(25) | 18(45) | 22(55) | 26(65) | 14(35) |
N2 | 28(78) | 8(22) | 20(56) | 16(44) | 8(22) | 28(78) |
N3 | 46(85) | 8(15) | 22(41) | 32(59) | 24(44) | 30(56) |
P | 0.001* | 0.094 | 0.045* | |||
ER | ||||||
(−ve) | 80(93) | 6(7) | 20(23) | 66(77) | 36(42) | 50(58) |
(+ve) | 76(57) | 58(43) | 62(46) | 72(54) | 66(49) | 68(51) |
P | 0.03* | 0.015* | 0.448 | |||
HR | ||||||
ER and PR −ve | 78(95) | 4(5) | 16(19) | 66(81) | 32(39) | 50(61) |
ER and/PR +ve | 78(56) | 60(44) | 66(48) | 72(52) | 70(51) | 68(49) |
P | 0.002* | 0.003* | 0.234 | |||
HER2/neu | ||||||
(−ve) | 74(54) | 64(46) | 44(32) | 94(68) | 72(52) | 66(48) |
(+ve) | 82(100) | 0(0) | 38(46) | 44(54) | 30(37) | 52(63) |
P | 0.001* | 0.129 | 0.113 | |||
Mol. class. | ||||||
Luminal A | 43(42) | 60(58) | 40(39) | 63(61) | 54(52) | 49(48) |
Luminal B | 39(100) | 0(0) | 26(67) | 13(33) | 17(44) | 22(56) |
HER2/neu +ve | 43(100) | 0(0) | 12(28) | 31(72) | 13(30) | 30(70) |
Triple −ve | 31(89) | 4(11) | 4(11) | 31(89) | 18(51) | 17 (49) |
P | 0.002* | 0.005* | 0.503 | |||