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Table 2 Clinicopathological features and expression of p53, p27, Ki-67, E-cadherin, and HER2 in UTUC

From: Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

Parameters

Category

p53

p27

Ki-67

E-cadherin

HER2

Negative n (%)

Positiven (%)

Negativen (%)

Positive n (%)

Negative n (%)

Positive n (%)

Positive n (%)

Negative n (%)

All cases

n = 66

42 (63.6)

24 (36.4)

6 (9.1)

60 (90.9)

20 (30.3)

46 (69.7)

66 (100)

66 (100)

Gender

Male (n = 49)

34 (51.5)

15 (22.7)

3 (4.5)

46 (69.7)

15 (22.7)

34 (51.5)

49 (74.2)

49 (74.2)

Female (n = 17)

8 (12.1)

9 (13.6)

3 (4.5)

14 (21.2)

5 (7.6)

12 (18.2)

17 (25.8)

17 (25.8)

Age (years)

≤ 60 (n = 14)

9 (13.6)

5 (7.6)

2 (3)

12 (18.2)

5 (7.6)

9 (13.6)

13 (19.7)

13 (19.7)

61–70 (n = 27)

20 (30.3)

7 (10.6)

3 (4.5)

24 (36.4)

11 (18.2)

16 (24.2)

28 (42.4)

28 (42.4)

≥ 71 (n = 25)

13 (19.7)

12 (18.2)

1 (1.5)

24 (36.4)

4 (6.1)

21 (31.8)

25 (37.9)

25 (37.9)

Stage

≤ pT1 (n = 19)

17 (25.7)

2 (3)

6 (9.1)

13 (19.7)

15 (22.7)

4 (6.1)

19 (28.8)

19 (28.8)

pT2-pT4 (n = 47)

25 (37.9)

22 (33.3)a

0

47 (71.2)a

5 (7.6)

42 (63.6)c

47 (71.2)

47 (71.2)

Grade

Low (n = 24)

18 (27.3)

6 (9.1)

6 (9.1)

18 (27.3)

16 (24.2)

8 (12.1)

24 (36.4)

24 (36.4)

High (n = 42)

24 (36.4)

18 (27.3)

0

42 (63.6)a

3 (4.5)

39 (59.1)c

42 (63.6)

42 (63.6)

Surgical margin

Healthy (n = 57)

40 (60.6)

17 (25.7)

4 (6.1)

53 (80.3)

16 (24.2)

40 (60.6)

57 (86.4)

57 (86.4)

Positive (n = 9)

2 (3)

7 (10.6)b

2 (3)

7 (10.6)

3 (4.5)

6 (9.1)

9 (13.6)

9 (13.6)

Tumor focality

Unifocal (n = 34)

19 (28.8)

15 (22.7)

5 (7.6)

29 (43.9)

9 (13.6)

25 (37.9)

34 (51.5)

34 (51.5)

Multifocal (n = 32)

23 (34.8)

9 (13.6)

1 (1.5)

31 (47)

11 (16.7)

21 (31.8)

32 (48.5)

32 (48.5)

Vascular invasion

Yes (n = 14)

7 (10.6)

7 (10.6)

0

14 (21.2)

0

14 (21.2)

14 (21.2)

14 (21.2)

No (n = 52)

35 (53)

17 (25.7)

6 (9.1)

46 (69.7)

20 (30.3)

32 (48.5)d

52 (78.8)

52 (78.8)

Nodal invasion

N+ (n = 5)

1 (1.5)

4 (6)

0

5 (7.6)

0

5 (7.6)

5 (7.6)

5 (7.6)

N0 (n = 18)

12 (18.2)

6 (9.1)

3 (4.5)

15 (22.7)

8 (12.1)

10 (15.1)

18 (27.3)

18 (27.3)

Nx (n = 43)

29 (43.9)

14 (21.2)

3 (4.5)

40 (60.6)

12 (18.2)

31 (47)

43 (65.1)

43 (65.1)

Tumor recurrence

Yes (n = 15)

8 (12.1)

7 (10.6)

2 (3)

13 (19.7)

7 (10.6)

8 (12.1)

15 (22.7)

15 (22.7)

No (n = 51)

34 (51.5)

17 (25.7)

4 (6.1)

47 (71.2)

13 (19.7)

38 (57.6)

51 (77.3)

51 (77.3)

  1. Only significant results were indicated with a: p = 0.001, b: p = 0.005, c: p < 0.001, d: p = 0.007