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Table 2 Clinicopathological features and expression of p53, p27, Ki-67, E-cadherin, and HER2 in UTUC

From: Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

Parameters Category p53 p27 Ki-67 E-cadherin HER2
Negative n (%) Positiven (%) Negativen (%) Positive n (%) Negative n (%) Positive n (%) Positive n (%) Negative n (%)
All cases n = 66 42 (63.6) 24 (36.4) 6 (9.1) 60 (90.9) 20 (30.3) 46 (69.7) 66 (100) 66 (100)
Gender Male (n = 49) 34 (51.5) 15 (22.7) 3 (4.5) 46 (69.7) 15 (22.7) 34 (51.5) 49 (74.2) 49 (74.2)
Female (n = 17) 8 (12.1) 9 (13.6) 3 (4.5) 14 (21.2) 5 (7.6) 12 (18.2) 17 (25.8) 17 (25.8)
Age (years) ≤ 60 (n = 14) 9 (13.6) 5 (7.6) 2 (3) 12 (18.2) 5 (7.6) 9 (13.6) 13 (19.7) 13 (19.7)
61–70 (n = 27) 20 (30.3) 7 (10.6) 3 (4.5) 24 (36.4) 11 (18.2) 16 (24.2) 28 (42.4) 28 (42.4)
≥ 71 (n = 25) 13 (19.7) 12 (18.2) 1 (1.5) 24 (36.4) 4 (6.1) 21 (31.8) 25 (37.9) 25 (37.9)
Stage ≤ pT1 (n = 19) 17 (25.7) 2 (3) 6 (9.1) 13 (19.7) 15 (22.7) 4 (6.1) 19 (28.8) 19 (28.8)
pT2-pT4 (n = 47) 25 (37.9) 22 (33.3)a 0 47 (71.2)a 5 (7.6) 42 (63.6)c 47 (71.2) 47 (71.2)
Grade Low (n = 24) 18 (27.3) 6 (9.1) 6 (9.1) 18 (27.3) 16 (24.2) 8 (12.1) 24 (36.4) 24 (36.4)
High (n = 42) 24 (36.4) 18 (27.3) 0 42 (63.6)a 3 (4.5) 39 (59.1)c 42 (63.6) 42 (63.6)
Surgical margin Healthy (n = 57) 40 (60.6) 17 (25.7) 4 (6.1) 53 (80.3) 16 (24.2) 40 (60.6) 57 (86.4) 57 (86.4)
Positive (n = 9) 2 (3) 7 (10.6)b 2 (3) 7 (10.6) 3 (4.5) 6 (9.1) 9 (13.6) 9 (13.6)
Tumor focality Unifocal (n = 34) 19 (28.8) 15 (22.7) 5 (7.6) 29 (43.9) 9 (13.6) 25 (37.9) 34 (51.5) 34 (51.5)
Multifocal (n = 32) 23 (34.8) 9 (13.6) 1 (1.5) 31 (47) 11 (16.7) 21 (31.8) 32 (48.5) 32 (48.5)
Vascular invasion Yes (n = 14) 7 (10.6) 7 (10.6) 0 14 (21.2) 0 14 (21.2) 14 (21.2) 14 (21.2)
No (n = 52) 35 (53) 17 (25.7) 6 (9.1) 46 (69.7) 20 (30.3) 32 (48.5)d 52 (78.8) 52 (78.8)
Nodal invasion N+ (n = 5) 1 (1.5) 4 (6) 0 5 (7.6) 0 5 (7.6) 5 (7.6) 5 (7.6)
N0 (n = 18) 12 (18.2) 6 (9.1) 3 (4.5) 15 (22.7) 8 (12.1) 10 (15.1) 18 (27.3) 18 (27.3)
Nx (n = 43) 29 (43.9) 14 (21.2) 3 (4.5) 40 (60.6) 12 (18.2) 31 (47) 43 (65.1) 43 (65.1)
Tumor recurrence Yes (n = 15) 8 (12.1) 7 (10.6) 2 (3) 13 (19.7) 7 (10.6) 8 (12.1) 15 (22.7) 15 (22.7)
No (n = 51) 34 (51.5) 17 (25.7) 4 (6.1) 47 (71.2) 13 (19.7) 38 (57.6) 51 (77.3) 51 (77.3)
  1. Only significant results were indicated with a: p = 0.001, b: p = 0.005, c: p < 0.001, d: p = 0.007