Parameters | Category | p53 | p27 | Ki-67 | E-cadherin | HER2 | |||
---|---|---|---|---|---|---|---|---|---|
Negative n (%) | Positiven (%) | Negativen (%) | Positive n (%) | Negative n (%) | Positive n (%) | Positive n (%) | Negative n (%) | ||
All cases | n = 66 | 42 (63.6) | 24 (36.4) | 6 (9.1) | 60 (90.9) | 20 (30.3) | 46 (69.7) | 66 (100) | 66 (100) |
Gender | Male (n = 49) | 34 (51.5) | 15 (22.7) | 3 (4.5) | 46 (69.7) | 15 (22.7) | 34 (51.5) | 49 (74.2) | 49 (74.2) |
Female (n = 17) | 8 (12.1) | 9 (13.6) | 3 (4.5) | 14 (21.2) | 5 (7.6) | 12 (18.2) | 17 (25.8) | 17 (25.8) | |
Age (years) | ≤ 60 (n = 14) | 9 (13.6) | 5 (7.6) | 2 (3) | 12 (18.2) | 5 (7.6) | 9 (13.6) | 13 (19.7) | 13 (19.7) |
61–70 (n = 27) | 20 (30.3) | 7 (10.6) | 3 (4.5) | 24 (36.4) | 11 (18.2) | 16 (24.2) | 28 (42.4) | 28 (42.4) | |
≥ 71 (n = 25) | 13 (19.7) | 12 (18.2) | 1 (1.5) | 24 (36.4) | 4 (6.1) | 21 (31.8) | 25 (37.9) | 25 (37.9) | |
Stage | ≤ pT1 (n = 19) | 17 (25.7) | 2 (3) | 6 (9.1) | 13 (19.7) | 15 (22.7) | 4 (6.1) | 19 (28.8) | 19 (28.8) |
pT2-pT4 (n = 47) | 25 (37.9) | 22 (33.3)a | 0 | 47 (71.2)a | 5 (7.6) | 42 (63.6)c | 47 (71.2) | 47 (71.2) | |
Grade | Low (n = 24) | 18 (27.3) | 6 (9.1) | 6 (9.1) | 18 (27.3) | 16 (24.2) | 8 (12.1) | 24 (36.4) | 24 (36.4) |
High (n = 42) | 24 (36.4) | 18 (27.3) | 0 | 42 (63.6)a | 3 (4.5) | 39 (59.1)c | 42 (63.6) | 42 (63.6) | |
Surgical margin | Healthy (n = 57) | 40 (60.6) | 17 (25.7) | 4 (6.1) | 53 (80.3) | 16 (24.2) | 40 (60.6) | 57 (86.4) | 57 (86.4) |
Positive (n = 9) | 2 (3) | 7 (10.6)b | 2 (3) | 7 (10.6) | 3 (4.5) | 6 (9.1) | 9 (13.6) | 9 (13.6) | |
Tumor focality | Unifocal (n = 34) | 19 (28.8) | 15 (22.7) | 5 (7.6) | 29 (43.9) | 9 (13.6) | 25 (37.9) | 34 (51.5) | 34 (51.5) |
Multifocal (n = 32) | 23 (34.8) | 9 (13.6) | 1 (1.5) | 31 (47) | 11 (16.7) | 21 (31.8) | 32 (48.5) | 32 (48.5) | |
Vascular invasion | Yes (n = 14) | 7 (10.6) | 7 (10.6) | 0 | 14 (21.2) | 0 | 14 (21.2) | 14 (21.2) | 14 (21.2) |
No (n = 52) | 35 (53) | 17 (25.7) | 6 (9.1) | 46 (69.7) | 20 (30.3) | 32 (48.5)d | 52 (78.8) | 52 (78.8) | |
Nodal invasion | N+ (n = 5) | 1 (1.5) | 4 (6) | 0 | 5 (7.6) | 0 | 5 (7.6) | 5 (7.6) | 5 (7.6) |
N0 (n = 18) | 12 (18.2) | 6 (9.1) | 3 (4.5) | 15 (22.7) | 8 (12.1) | 10 (15.1) | 18 (27.3) | 18 (27.3) | |
Nx (n = 43) | 29 (43.9) | 14 (21.2) | 3 (4.5) | 40 (60.6) | 12 (18.2) | 31 (47) | 43 (65.1) | 43 (65.1) | |
Tumor recurrence | Yes (n = 15) | 8 (12.1) | 7 (10.6) | 2 (3) | 13 (19.7) | 7 (10.6) | 8 (12.1) | 15 (22.7) | 15 (22.7) |
No (n = 51) | 34 (51.5) | 17 (25.7) | 4 (6.1) | 47 (71.2) | 13 (19.7) | 38 (57.6) | 51 (77.3) | 51 (77.3) |