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Table 5 Association of the different genotypes of glutathione S-transferase P1 with some prognostic factors of HCC using chi-square test

From: Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma

 

GSTP1 homo hetero vs wild

p value

 

Heterozygous variant

Homozygous variant

Wild

X2

N (%)

N (%)

N (%)

  

Age (years)

< 54

20 (45.5)

8 (80)

23 (51.1)

0.142

3.899

≥ 55

24 (54.5)

2 (20)

22 (48.9)

  

Gender

Female

13 (29.5)

1 (10.0)

10 (10.0)

0.391

1.878

Male

31 (70.5)

9 (90.0)

35 (77.8)

  

Tumor size

≤ 3 cm

16 (36.4)

4 (40.0)

16 (35.6)

0.966

0.070

> 3 cm

28 (63.6)

6 (60.0)

29 (64.4)

  

No. of focal lesions

1

24 (54.5)

4 (40.0)

23 (51.1)

0.286

0.381

2

3 (6.8)

3 (30.0)

8 (17.8)

  

3

4 (9.1)

1 (10.0)

1 (2.2)

  

More than 3

13 (29.5)

2 (20.0)

13 (28.9)

  

Stage

Early stage (I, II)

12 (27.3)

3 (30.0)

11 (24.4.0)

0.918

0.172

Late stage (III, IV)

32 (72.7)

7 (70.0)

34 (75.6)

  

Child score

A

23 (53.3)

8 (80.0)

26 (57.8)

  

B

21 (47.7)

1 (10.0)

18 (40.0)

  

C

0 (0)

1 (10.0)

1 (2.2)

  

Distant metastasis

No

42 (95.5)

8 (8.1)

36 (36.4)

0.077

5.118

Yes

2 (4.5)

2 (2.0)

9 (9.1)

  

Liver cirrhosis

Negative

1 (2.3)

0 (0.0)

1 (2.2)

  

Positive

43 (97.7)

10 (100.0)

44 (97.8)

  

Portal vein

Thrombosed

6 (13.6)

6 (60.0)

8 (17.8)

0.004

9.700

Patent

38 (86.4)

4 (40.0)

37 (82.2)

  

Splenomegaly

−ve

15 (34.1)

5 (50.0)

17 (37.8)

0.642

2.037

+ve

29 (65.9)

5 (50.0)

28 (62.2)

  

Ascites

Present

16 (36.4)

4 (40.0)

20 (44.4)

0.739

0.292

Absent

28 (63.6)

6 (60.0)

25 (55.6)

  

L.Ns

−ve

39 (88.6)

8 (80.0)

26 (57.8)

0.004

4.905

+ve

5 (11.4)

2 (20.0)

19 (42.2)

  

Family history of HCC

Negative

37 (84.1)

7 (70.0)

43 (95.6)

0.048

5.286

Positive

7 (15.9)

3 (30.0)

2 (4.4)

  

HBV infection

B−ve

42 (95.5)

10 (100.0)

44 (97.8)

*

 

B + ve

2 (4.5)

0 (0.0)

1 (2.2)

  

HCV infection

C−ve

6 (13.6)

0 (0.0)

10 (22.2)

0.187

3.355

C + ve

38 (86.4)

10 (100.0)

35 (77.8)

  
  1. Significant p value ≤ 0.05
  2. Number and percentage in parenthesis
  3. GSTP1 glutathione S-transferase P1, GSTP1 glutathione S-transferase P1
  4. *p value cannot be assessed due to small number
  5. *Significant p value ≤ 0.05