Table 4 Relation between combined densities of CD68 expression in both tumor nest and stroma and clinicopathologic characteristics
Total | CD68-positive TAMs | p | ||||
|---|---|---|---|---|---|---|
TNLow and TSLow A N = 17 N (%) | TNHigh and TSLow B N = 13 N (%) | TNHigh and TSHigh C N = 16 N (%) | TNLow and TSHigh D N = 14 N (%) | |||
Age (years) mean ± SD | 52.88 ± 13.71 | 51.23 ± 10.32 | 48.13 ± 12.25 | 51.22 ± 11.64 | 0.646 | |
Size | ||||||
< 5 cm | 39 | 13 (33.3) | 12 (30.8) | 4 (10.3) | 10 (25.6) | 0.001* |
≥ 5 cm | 21 | 4 (19) | 1 (4.8) | 12 (57.2) | 4 (19) | |
Pairwise comparison: AB: 0.248, AC: 0.003*, AD:0.749, BC: < 0.001*, BD: 0.326, CD: 0.026* | ||||||
Grade | ||||||
GII | 32 | 10 (31.3) | 8 (25) | 6 (18.7) | 8 (25) | 0.545 |
GIII | 28 | 7 (25) | 5 (17.9) | 10 (35.7) | 6 (21.4) | |
Nodal metastasis | ||||||
Negative | 26 | 12 (46.2) | 5 (19.2) | 4 (15.4) | 5 (19.2) | 0.053 |
Positive | 34 | 5 (14.7) | 8 (23.5) | 12 (35.3) | 9 (26.5) | |
Stage | ||||||
I | 3 | 2 (66.7) | 1 (33.3) | 0 | 0 | 0.119 |
II | 32 | 10 (31.3) | 7 (21.9) | 5 (15.5) | 10 (31.3) | |
III | 25 | 5 (20) | 5 (20) | 11 (44) | 14 (16) | |
Vascular invasion | ||||||
Negative | 22 | 6 (27.3) | 9 (40.9) | 4 (18.2) | 3 (13.6) | 0.048* |
Positive | 38 | 11 (28.9) | 4 (10.5) | 12 (31.7) | 11 (28.9) | |
Pairwise comparison: AB: 0.139, AC: 0.707, AD: 0.456, BC: 0.027*, BD: 0.021*, CD:1 | ||||||
ER | ||||||
Negative | 13 | 3 (23.1) | 4 (30.7) | 3 (23.1) | 3 (23.1) | 0.862 |
Positive | 47 | 14 (29.8) | 9 (19.1) | 13 (27.7) | 11 (23.4) | |
PR | ||||||
Negative | 26 | 7 (26.9) | 7 (26.9) | 5 (19.3) | 7 (26.9) | 0.628 |
Positive | 34 | 10 (29.4) | 6 (17.6) | 11 (32.4) | 14 (20.6) | |
Her2 | ||||||
Negative | 45 | 12 (26.7) | 11 (24.4) | 12 (26.7) | 10 (22.2) | 0.845 |
Positive | 15 | 5 (33.3) | 2 (13.3) | 4 (26.7) | 4 (26.7) | |
Ki-67 | ||||||
≤ 14% | 29 | 8 (27.6) | 7 (24.1) | 6 (20.7) | 8 (27.6) | 0.745 |
> 14% | 31 | 9 (29) | 6 (19.4) | 10 (32.2) | 6 (19.4) | |
Molecular subtypes | ||||||
Luminal A | 27 | 7 (25.9) | 7 (25.9) | 5 (18.6) | 8 (29.6) | 0.284 |
Luminal B | 24 | 8 (33.3) | 2 (8.4) | 9 (37.5) | 5 (20.8) | |
Triple negative | 9 | 2 (22.2) | 4 (44.5) | 2 (22.2) | 1 (11.1) | |