Table 2 The reported stimuli-responsive nanocarriers for the treatment of OS
Type of nanocarrier | Drug | Type of stimuli | Performance | Reference |
|---|---|---|---|---|
NPs | DOX and PTX | reduction/pH | In vitro: significantly higher cytotoxicity against K7 cells than plain DOX NPs and PTX NPs, and free DOX and PTX. | [47] |
Hydrogel | MTX and ALD | Thermosensitive | In vitro: sustained release of both MTX and ALD. In vivo: significant tumor inhibition activity in mice. | [48] |
CeO2NPs | DOX | pH sensitive | In vitro: exhibited pH dependent sustained and controlled release of DOX. | [49] |
Liposomes | DOX | Reduction and (GSH) sensitive | In vitro: remarkable cytotoxicity to MG63 OS cells than LO2 liver cells. | [50] |
Hydrogel | PLK1-shRNA and DOX | Thermosensitive | In vitro: remarkable cytotoxicity than single drug-loaded hydrogels. | [51] |