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Journal of the Egyptian National Cancer Institute
Fig. 1 | Journal of the Egyptian National Cancer Institute

Fig. 1

From: Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups

Fig. 1

Histopathological and immunohistochemical results of MB cases. (a) H&E sections of classic histology (× 400), (b) nuclear immunoreactivity for β-catenin (× 400), (c) negative cytoplasmic staining for GAB1 (× 200); Both b and c characterize WNT pathway of MB, (d) H&E sections of D/N histology revealed nodular configuration with intervening desmoplasia (× 200), (e) negative nuclear expression for β-catenin (with cytoplasmic immunoreactivity) (× 400), (f) strong cytoplasmic staining for GAB1 (× 400); both e and f denote SHH profile, (g) H&E sections of large cell MB, (h) negative nuclear expression for β-catenin (with cytoplasmic reaction) (× 400), (i) negative cytoplasmic reactivity for GAB1 (× 400), (j) H&E sections of anaplastic MB with rhabdoid features exhibiting abundant eosinophilic glassy cytoplasm with eccentric nuclei and scattered multinucleated giant cells; confirmed by positive cytoplasmic staining for synaptophysin (inset) (× 400), (k) negative nuclear/positive cytoplasmic expression for β-catenin (× 400), (l) negative cytoplasmic reaction for GAB1 (× 400); h, i, k, and l characterize non-WNT/SHH subgroup of MB

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