Histopathological types | P value | |||
---|---|---|---|---|
Classic medulloblastoma (n = 14) | Desmoplastic /Nodular medulloblastoma (n = 10) | Large cell/anaplastic medulloblastoma (n = 16) | ||
Age group (years) | ||||
< 3 (infants) | 3 (21.4%) | 2 (20%) | 3 (18.8%) | MC, p = 0.073 |
3-16 (pediatric age) | 11 (78.6%) | 4 (40%) | 12 (75%) | |
> 16 (adults) | 0 (0%) | 4 (40%) | 1 (6.3%) | |
Sex | ||||
Male | 9 (64.3%) | 4 (40%) | 9 (56.3%) | p = 0.495 |
Female | 5 (35.7%) | 6 (60%) | 7 (43.8%) | |
Location of the mass | ||||
Midline | 13 (92.9%) | 1 (10%) | 13 (81.3%) | MC, p < 0.001* |
Lateral | 1 (7.1%) | 9 (90%) | 3 (18.8%) | |
Degree of anaplasia | ||||
Slight anaplasia | 4 (28.6%) | 3 (30%) | 0 (0%) | MC, p = 0.014* |
Moderate anaplasia | 7 (50%) | 4 (40%) | 4 (25%) | |
Severe anaplasia | 3 (21.4%) | 3 (30%) | 12 (75%) | |
Molecular subgroups | ||||
WNT | 3 (21.4%) | 0 (0%) | 1 (6.3%) | MC, p < 0.01* |
SHH | 0 (0%) | 10 (100%) | 2 (12.5%) | |
Non-WNT/SHH | 11 (78.6%) | 0 (0%) | 13 (81.3%) | |
Risk stratification | ||||
Standard risk | 7 (50%) | 8 (80%) | 3 (18.8%) | p < 0.008* |
High risk | 7 (50%) | 2 (20%) | 13 (81.3%) |