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Table 3 Relation of histopathological types to clinicopathological parameters

From: Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups

 

Histopathological types

P value

 

Classic medulloblastoma (n = 14)

Desmoplastic /Nodular medulloblastoma (n = 10)

Large cell/anaplastic medulloblastoma (n = 16)

Age group (years)

    

 < 3 (infants)

3 (21.4%)

2 (20%)

3 (18.8%)

MC, p = 0.073

 3-16 (pediatric age)

11 (78.6%)

4 (40%)

12 (75%)

 > 16 (adults)

0 (0%)

4 (40%)

1 (6.3%)

Sex

    

 Male

9 (64.3%)

4 (40%)

9 (56.3%)

p = 0.495

 Female

5 (35.7%)

6 (60%)

7 (43.8%)

Location of the mass

    

 Midline

13 (92.9%)

1 (10%)

13 (81.3%)

MC, p < 0.001*

 Lateral

1 (7.1%)

9 (90%)

3 (18.8%)

Degree of anaplasia

    

 Slight anaplasia

4 (28.6%)

3 (30%)

0 (0%)

MC, p = 0.014*

 Moderate anaplasia

7 (50%)

4 (40%)

4 (25%)

 Severe anaplasia

3 (21.4%)

3 (30%)

12 (75%)

Molecular subgroups

    

 WNT

3 (21.4%)

0 (0%)

1 (6.3%)

MC, p < 0.01*

 SHH

0 (0%)

10 (100%)

2 (12.5%)

 Non-WNT/SHH

11 (78.6%)

0 (0%)

13 (81.3%)

Risk stratification

    

 Standard risk

7 (50%)

8 (80%)

3 (18.8%)

p < 0.008*

 High risk

7 (50%)

2 (20%)

13 (81.3%)

  1. MC Monte Carlo
  2. *Statistically significant at p ≤ 0.05