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Table 3 Relation of histopathological types to clinicopathological parameters

From: Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups

  Histopathological types P value
  Classic medulloblastoma (n = 14) Desmoplastic /Nodular medulloblastoma (n = 10) Large cell/anaplastic medulloblastoma (n = 16)
Age group (years)     
 < 3 (infants) 3 (21.4%) 2 (20%) 3 (18.8%) MC, p = 0.073
 3-16 (pediatric age) 11 (78.6%) 4 (40%) 12 (75%)
 > 16 (adults) 0 (0%) 4 (40%) 1 (6.3%)
Sex     
 Male 9 (64.3%) 4 (40%) 9 (56.3%) p = 0.495
 Female 5 (35.7%) 6 (60%) 7 (43.8%)
Location of the mass     
 Midline 13 (92.9%) 1 (10%) 13 (81.3%) MC, p < 0.001*
 Lateral 1 (7.1%) 9 (90%) 3 (18.8%)
Degree of anaplasia     
 Slight anaplasia 4 (28.6%) 3 (30%) 0 (0%) MC, p = 0.014*
 Moderate anaplasia 7 (50%) 4 (40%) 4 (25%)
 Severe anaplasia 3 (21.4%) 3 (30%) 12 (75%)
Molecular subgroups     
 WNT 3 (21.4%) 0 (0%) 1 (6.3%) MC, p < 0.01*
 SHH 0 (0%) 10 (100%) 2 (12.5%)
 Non-WNT/SHH 11 (78.6%) 0 (0%) 13 (81.3%)
Risk stratification     
 Standard risk 7 (50%) 8 (80%) 3 (18.8%) p < 0.008*
 High risk 7 (50%) 2 (20%) 13 (81.3%)
  1. MC Monte Carlo
  2. *Statistically significant at p ≤ 0.05