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Table 1 Reverse virtual screening analyses of AKBA against selected proteins

From: Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells

Target protein

PDB entry

Binding scores (kcal/mol)

FOXM1

3G738

 − 5.2

Aurora kinase

4BYJ9

 − 7.9

CHK1

2C3K10

 − 8.5

PLK1

2RKU11

 − 7.7

CDC25C

3OP312

 + 230.9

Cyclin B1

6GU413

 − 6.7

p-CDK1

6GU413

 − 9.2

TOP2A

5GWK14

 − 6.3

PI3K

5JHB15

 − 8.5

Akt

3D0E16

 − 0.6

HER2

3PP017

2.1

c-MET

4KNB18

 − 7.9

TP53

5O1C19

 − 5.2

MDM2

5LN220

 − 6.8

JAK

3KRR21

 − 6.8

STAT3

6NUQ22

 − 6.9

MAPK

5MTX23

 − 8.9

VEGFR

4AGD24

 − 6..6

Caspase 7

1I5125

 − 7.3

Caspase 3

1RHQ26

 − 7.4

Src

3EL727

 − 8.7

B-Raf

3C4C28

 − 8.8

EGFR

5XDL29

 − 8.6