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Table 1 Reverse virtual screening analyses of AKBA against selected proteins

From: Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells

Target protein PDB entry Binding scores (kcal/mol)
FOXM1 3G738  − 5.2
Aurora kinase 4BYJ9  − 7.9
CHK1 2C3K10  − 8.5
PLK1 2RKU11  − 7.7
CDC25C 3OP312  + 230.9
Cyclin B1 6GU413  − 6.7
p-CDK1 6GU413  − 9.2
TOP2A 5GWK14  − 6.3
PI3K 5JHB15  − 8.5
Akt 3D0E16  − 0.6
HER2 3PP017 2.1
c-MET 4KNB18  − 7.9
TP53 5O1C19  − 5.2
MDM2 5LN220  − 6.8
JAK 3KRR21  − 6.8
STAT3 6NUQ22  − 6.9
MAPK 5MTX23  − 8.9
VEGFR 4AGD24  − 6..6
Caspase 7 1I5125  − 7.3
Caspase 3 1RHQ26  − 7.4
Src 3EL727  − 8.7
B-Raf 3C4C28  − 8.8
EGFR 5XDL29  − 8.6