Gene | Protein name | Role in cell cycle regulation |
---|---|---|
AURKB | Aurora kinase B | Maintains kinetochore-microtubule association in metaphase and relocalizes to the midbody of the cell from anaphase to telophase |
PLK1 | Polo-like kinase 1 | Regulates centrosome disjunction, activates of cyclin and cyclin-dependent kinases (CDKs), spindle assembly, and chromosome separation |
TPX2 | Targeting protein for Xklp2 | Forms the mitotic spindle by activates the Aurora kinase A |
CDK1 | Cyclin-dependent kinase 1 | Promotes cell cycle progression from G2 to mitosis by generating chromosome condensation and microtubule dynamics |
AURKA | Aurora kinase A | Favors G2 to mitosis transitioning and contributes to centrosome separation |
KIF11 | Kinesin family member 11 | Intercedes centrosome segregation and conformation of the bipolar mitotic spindle |
CDC7 | Cell division cycle 7-kinase | Stimulates Aurora kinase B activity during mitosis progression |
CHEK1 | Checkpoint kinase 1 | Relieves cyclin B/Cdk1 in the nucleus during mitosis, targets spindle assembly checkpoint proteins |
CDC25B | M-phase inducer phosphatase 2 | Promotes progression from G2 to mitosis by activating Cdk1/cyclin B complex for centrosome microtubule nucleation, phosphorylates Aurora-A to permit entry into mitosis by giving the first stimulus of Cdk1 activity |