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Table 1 The CPTGs which involved in the G2/M checkpoint hallmark according to MSigDB

From: The integrative bioinformatic analysis deciphers the predicted molecular target gene and pathway from curcumin derivative CCA-1.1 against triple-negative breast cancer (TNBC)

Gene

Protein name

Role in cell cycle regulation

AURKB

Aurora kinase B

Maintains kinetochore-microtubule association in metaphase and relocalizes to the midbody of the cell from anaphase to telophase

PLK1

Polo-like kinase 1

Regulates centrosome disjunction, activates of cyclin and cyclin-dependent kinases (CDKs), spindle assembly, and chromosome separation

TPX2

Targeting protein for Xklp2

Forms the mitotic spindle by activates the Aurora kinase A

CDK1

Cyclin-dependent kinase 1

Promotes cell cycle progression from G2 to mitosis by generating chromosome condensation and microtubule dynamics

AURKA

Aurora kinase A

Favors G2 to mitosis transitioning and contributes to centrosome separation

KIF11

Kinesin family member 11

Intercedes centrosome segregation and conformation of the bipolar mitotic spindle

CDC7

Cell division cycle 7-kinase

Stimulates Aurora kinase B activity during mitosis progression

CHEK1

Checkpoint kinase 1

Relieves cyclin B/Cdk1 in the nucleus during mitosis, targets spindle assembly checkpoint proteins

CDC25B

M-phase inducer phosphatase 2

Promotes progression from G2 to mitosis by activating Cdk1/cyclin B complex for centrosome microtubule nucleation, phosphorylates Aurora-A to permit entry into mitosis by giving the first stimulus of Cdk1 activity