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Table 1 Comparison of different reported cases of intussusception in children with Acute Lymphoblastic Leukemia

From: Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review – a case report

Serial Name of study (year) Number of cases Location Cause Treatment Stage Treatment and Outcome
1 Shalaby et al. (2014) [12] 1 Left sided Colo-colic No lead point seen Three days prior to completion of induction Surgical reduction. No recurrence
2 Shah et al. (2006) [15] 2 Case 1: Ceco-colic
Case 2: Ileo-colic
Possible correlation between high dose methotrexate and intussusception Case 1: 9th week of consolidation
Case 2: 14th week of consolidation
Case 1 and Case 2: Reduction by barium enema followed by supportive treatment
3 Arestis et al. (2005) [6] 2 Case 1: Ileocecal
Case 2: Descending colon
Case1: Vincristine mediated ileus
Case 2: Non leukemic lymph node acting as lead point
Case 1: Day 8 of induction
Case 2: Day 10 after completion of 13 cycles of vincristine
Case 1: Surgical reduction. No recurrences
Case 2: Laparotomy with Hemicolectomy
4 Manglani et al. (1998) [2] 1 Ileo-cecal Necrotic mucosa actin as lead point after leukemic infiltration Day 4 of induction Surgery followed by chemotherapy and bone marrow transplant. Patient could not be saved
5 Gavan et al. (1994) [11] 2 Case 1: Ileo-colic
Case 2: Ceco-colic
Case 1: Enlarged lymph nodes as lead point
Case 2: Unknown
Case 1: Day 11 of induction
Case 2: Day 8 of induction
Case 1: Irreducible lesion. Treatment not documented
Case 2: Surgical reduction
6 Micallef-Eynaud (1990) [4] 1 Ceco-colic Vincristine associated bowel dysfunction along with typhlitis Day 8 of induction Surgical reduction followed by antibiotics for sepsis. Patient attained remission
7 Feldman et al. (1963) [16] 1 Upper Ileum Leukemic infiltration of mucosa causing a hematoma 9 months after initiation of mercaptopurine Antibiotics and supportive therapy. Patient succumbed in 48 h