Table 1 Comparison of different reported cases of intussusception in children with Acute Lymphoblastic Leukemia
Serial | Name of study (year) | Number of cases | Location | Cause | Treatment Stage | Treatment and Outcome |
|---|---|---|---|---|---|---|
1 | Shalaby et al. (2014) [12] | 1 | Left sided Colo-colic | No lead point seen | Three days prior to completion of induction | Surgical reduction. No recurrence |
2 | Shah et al. (2006) [15] | 2 | Case 1: Ceco-colic Case 2: Ileo-colic | Possible correlation between high dose methotrexate and intussusception | Case 1: 9th week of consolidation Case 2: 14th week of consolidation | Case 1 and Case 2: Reduction by barium enema followed by supportive treatment |
3 | Arestis et al. (2005) [6] | 2 | Case 1: Ileocecal Case 2: Descending colon | Case1: Vincristine mediated ileus Case 2: Non leukemic lymph node acting as lead point | Case 1: Day 8 of induction Case 2: Day 10 after completion of 13 cycles of vincristine | Case 1: Surgical reduction. No recurrences Case 2: Laparotomy with Hemicolectomy |
4 | Manglani et al. (1998) [2] | 1 | Ileo-cecal | Necrotic mucosa actin as lead point after leukemic infiltration | Day 4 of induction | Surgery followed by chemotherapy and bone marrow transplant. Patient could not be saved |
5 | Gavan et al. (1994) [11] | 2 | Case 1: Ileo-colic Case 2: Ceco-colic | Case 1: Enlarged lymph nodes as lead point Case 2: Unknown | Case 1: Day 11 of induction Case 2: Day 8 of induction | Case 1: Irreducible lesion. Treatment not documented Case 2: Surgical reduction |
6 | Micallef-Eynaud (1990) [4] | 1 | Ceco-colic | Vincristine associated bowel dysfunction along with typhlitis | Day 8 of induction | Surgical reduction followed by antibiotics for sepsis. Patient attained remission |
7 | Feldman et al. (1963) [16] | 1 | Upper Ileum | Leukemic infiltration of mucosa causing a hematoma | 9 months after initiation of mercaptopurine | Antibiotics and supportive therapy. Patient succumbed in 48 h |