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Journal of the Egyptian National Cancer Institute

Table 1 Mean IC50 values for glufosfamide or ifosfamide in HepG2 cells following different incubation time periods

From: An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Incubation time

HepG2 Cells

Glufosfamide

Ifosfamide

24 h

112.32*,a ± 8.5

133.0*,b ± 8.9

48 h

83.23*,a ± 5.6

125.0*,b ± 11.2

72 h

51.66*,a ± 3.2

100.20*,b ± 7.6

  1. Data represent mean ± SE, n = 6 (Each concentration was processed in triplicate; each experiment was done twice)
  2. IC50 values were in µM
  3. Each drug was added to culture medium at concentration range; 10–1000 µM
  4. HepG2 cells were seeded at 5000–10,000 cells per well
  5. Cytotoxicity was assessed using MTT assay
  6. *Data in rows having the same superscript are significantly different from each other at P < 0.05 using independent two-tailed Student’s t test
  7. a, bData in columns having the same superscript are significantly different from each other at P < 0.05 using one way analysis of variance (ANOVA) followed by Tukey as post hoc test
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