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Table 2 Effects of glufosfamide on the frequency of apoptosis in HepG2 cells

From: An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Time period Control Glufosfamide (µM)1
10 25 50
48 h 3.1 ± 0.1a 10.9a ± 0.9 18.2a ± 1.2 35.9a ± 2.1
72 h 3.5 ± 0.9b 18.7*,b ± 1.5 27.6*,b ± 1.7 46.8*,b ± 2.5
  1. Data represent mean ± SE, n = 3
  2. 1Glufosfamide was used in its IC50 value beside two of its fractions; 10 and 25 µM
  3. The number of HepG2 cells used was in the range of 5 × 105 ~ 5 × 106 cells/mL
  4. Percent apoptosis was calculated as the sum of frequencies of cells in late apoptosis and those undergoing apoptosis
  5. *Significantly different from the same concentration incubated with HepG2 cells for 48 h at P < 0.05, using independent two-tailed Student’s t test
  6. a,bData in the same rows having the same superscript are significantly different from each other at P < 0.05 using one-way analysis of variance (ANOVA) followed by Tukey as post hoc test