Time period | Control | Glufosfamide (µM)1 |
|---|
10 | 25 | 50 |
|---|
48 h | 3.1 ± 0.1a | 10.9a ± 0.9 | 18.2a ± 1.2 | 35.9a ± 2.1 |
72 h | 3.5 ± 0.9b | 18.7*,b ± 1.5 | 27.6*,b ± 1.7 | 46.8*,b ± 2.5 |
- Data represent mean ± SE, n = 3
- 1Glufosfamide was used in its IC50 value beside two of its fractions; 10 and 25 µM
- The number of HepG2 cells used was in the range of 5 × 105 ~ 5 × 106 cells/mL
- Percent apoptosis was calculated as the sum of frequencies of cells in late apoptosis and those undergoing apoptosis
- *Significantly different from the same concentration incubated with HepG2 cells for 48 h at P < 0.05, using independent two-tailed Student’s t test
- a,bData in the same rows having the same superscript are significantly different from each other at P < 0.05 using one-way analysis of variance (ANOVA) followed by Tukey as post hoc test
