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Table 3 Effects of ifosfamide on the frequency of apoptosis in HepG2 cells

From: An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Time period Control Ifosfamide (µM)1
25 50 100
48 h 3.1 ± 0.1a 8.2a ± 0.9 13.2a ± 1.1 18.6a ± 1.5
72 h 3.5 ± 0.9b 10.4*,b ± 0.6 16.8*,b ± 1.3 24.5*,b ± 2.1
  1. Data represent mean ± SE, n = 3
  2. 1Ifosfamide was used in its IC50 value beside two of its fractions; 25 and 50 µM
  3. The number of HepG2 cells used was in the range of 5 × 105 ~ 5 × 106 cells/mL
  4. Percent apoptosis was calculated as the sum of frequencies of cells in late apoptosis and those undergoing apoptosis
  5. *Significantly different from the same concentration incubated with HepG2 cells for 48 h at P < 0.05, using independent Student’s t test
  6. a,bData in the same rows having the same superscript are significantly different from each other at P < 0.05 using one-way analysis of variance (ANOVA) followed by Tukey as post hoc test