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Journal of the Egyptian National Cancer Institute

Table 5 Effects of ifosfamide on caspase-9 content in cell lysate of cultured HepG2 cells

From: An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Time period

Control

Ifosfamide (µM)1

25

50

100

48 h

4.0 ± 0.2a

12.1a ± 0.7

20.3a ± 1.4

30.9a ± 3.1

72 h

4.2 ± 0.5b

15.0*,b ± 1.3

28.1*,b ± 1.9

40.75*,b ± 2.3

  1. Data represent mean ± SE, n = 3
  2. 1Ifosfamide was used in its IC50 value beside two of its fractions; 25 and 50 µM
  3. The number of HepG2 cells used was in the range of 5 × 105 ~ 5 × 106 cells/mL
  4. Caspase-9 content was expressed as ng/mL
  5. *Significantly different from the same concentration incubated with HepG2 cells for 48 h at P < 0.05, using independent Student’s t test
  6. a,bData in the same rows having the same superscript are significantly different from each other at P < 0.05 using one-way analysis of variance (ANOVA) followed by Tukey as post hoc test
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