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Journal of the Egyptian National Cancer Institute

Table 1 Details of anti-diabetic compounds selected for study and their hERG blocking profile

From: Non-cancer to anti-cancer: investigation of human ether-a-go-go-related gene potassium channel inhibitors as potential therapeutics

Drug

Prediction/potency

Confidence

Applicability domain (AD)

Acarbose

Potential cardiotoxic (+)

50%

No

(Value =0.16, limit=0.26)

Weak/moderate

50%

Alrestatin

Non-cardiotoxic (−)

60%

No

(Value =0.24, limit=0.26)

Not applicable

 

Acetohexamide

Non-cardiotoxic (−)

80%

Yes

(Value =0.31, limit=0.26)

Not applicable

 

Anagliptin

Non-cardiotoxic (−)

80%

Yes

(Value =0.29, limit=0.26)

Not applicable

 

Alogliptin

Non-cardiotoxic (−)

60%

Yes

(Value =0.39, limit=0.26)

Not applicable

 

Buformin

Non-cardiotoxic (−)

50

No

(Value =0.16, limit=0.26)

Not applicable

 

Bromocriptine

Potential cardiotoxic (+)

60

Yes

(Value =0.26, limit=0.26)

Weak/moderate

50

Balaglitazone

Potential cardiotoxic (+)

60

Yes

(Value =0.34, limit=0.26)

Weak/moderate

60

Carbutamide

Non-cardiotoxic (−)

70

Yes

(Value =0.29, limit=0.26)

Not applicable

 

Canagliflozin

Non-cardiotoxic (−)

50

No

(Value =0.25, limit=0.26)

Not applicable

 

Ciglitazone

Non-cardiotoxic (−)

50

Yes

(Value =0.26, limit=0.26)

Not applicable

 

Chlorpropamide

Non-cardiotoxic (−)

70

Yes

(Value=0.31, limit=0.26)

Not applicable

 

Darglitazone

Potential cardiotoxic (+)

50

Yes

(Value =0.3, limit=0.26)

Weak/moderate

60

Empagliflozin

Potential cardiotoxic (+)

60

Yes

(Value =0.28, limit=0.26)

Strong/extreme

50

Dapagliflozin

Potential cardiotoxic (+)

60

Yes

(Value =0.29, limit=0.26)

Strong/extreme

50

Englitazone

Potential cardiotoxic (+)

60

Yes

(Value =0.28, limit=0.26)

Strong/extreme

50

Epalrestat

Non-cardiotoxic (−)

60

No

(Value =0.24, limit=0.26)

 

Not applicable

  

Ertugliflozin

Non-cardiotoxic (−)

60

Yes

(Value =0.3, limit=0.26)

Not applicable

  

Euogliptin

Non-cardiotoxic (−)

80

Yes

(Value =0.28, limit=0.26)

Not applicable

  

Fidarestat

Non-cardiotoxic (−)

60

No

(Value =0.25, limit=0.26)

Not applicable

 

Glibenclamide

Non-cardiotoxic (−)

80

Yes

(Value =0.34, limit=0.26)

Not applicable

 

Gemigliptin

Non-cardiotoxic (−)

60

No

(Value =0.24, limit=0.26)

Not applicable

 

Gliclazide

Non-cardiotoxic (−)

70

Yes

(Value =0.3, limit=0.26)

Not applicable

 

Glibornuride

Non-cardiotoxic (−)

70

Yes

(Value =0.28, limit=0.26)

Not applicable

 

Glimepride

Non-cardiotoxic (−)

70

No

(Value =0.31, limit=0.26)

Not applicable

 

Gliquidone

Non-cardiotoxic (−)

50

Yes

(Value =0.35, limit=0.26)

Not applicable

 

Glipizide

Non-cardiotoxic (−)

60

Yes

(Value =0.32, limit=0.26)

Not applicable

 

Gosogliptin

Non-cardiotoxic (−)

90

Yes

(Value =0.29, limit=0.26)

Not applicable

 

Glyclopyramide

Non-cardiotoxic (−)

70

Yes

(Value =0.35, limit=0.26)

Not applicable

 

Glisoxepide

Non-cardiotoxic (−)

50

Yes

(Value =0.33, limit=0.26)

Not applicable

 

Imirestat

Non-cardiotoxic (−)

60%

No

(Value =0.24, limit=0.26)

Not applicable

 

Linogliride

Non-cardiotoxic (−)

70%

Yes

(Value =0.27, limit=0.26)

Not applicable

 

Linagliptin

Non-cardiotoxic (−)

80%

Yes

(Value =0.4, limit=0.26)

Not applicable

 

Lidorestat

Non-cardiotoxic (−)

60%

No

(Value =0.25, limit=0.26)

Not applicable

 

Ipragliflozin

Potential cardiotoxic (+)

50%

No

(Value =0.23, limit=0.26)

Weak/Moderate

50%

Lobeglitazone

Potential cardiotoxic (+)

60%

Yes

(Value =0.27, limit=0.26)

Weak/Moderate

60%

 

Luseogliflozin

Potential cardiotoxic (+)

50%

Yes

(Value =0.28, limit=0.26)

Weak/moderate

50%

Meglitinide

Potential cardiotoxic (+)

50%

Yes

(Value =0.32, limit=0.26)

 

Weak/moderate

60%

Metahexamide

Non-cardiotoxic (−)

80%

Yes

(Value =0.3, limit=0.26)

Not applicable

 

Metformin

Non-cardiotoxic (−)

70%

No

(Value =0.14, limit=0.26)

Not applicable

 

Mifepristone

Potential cardiotoxic (+)

60%

No

(Value =0.21, limit=0.26)

Weak/moderate

50%

Miglitol

Non-cardiotoxic (−)

70%

No

(Value =0.16, limit=0.26)

Not applicable

 

Mitiglinide

Non-cardiotoxic (−)

60%

Yes

(Value =0.29, limit=0.26)

Not applicable

 

Minalirestat

Potential cardiotoxic (+)

50%

Yes

(Value =0.26, limit=0.26)

Weak/moderate

60

Nateglinide

Non-cardiotoxic (−)

60%

Yes

(Value =0.31, limit=0.26)

Not applicable

 

Netoglitazone

Non-cardiotoxic (−)

50%

Yes

(Value =0.28, limit=0.26)

Not applicable

 

Omarigliptin

Non-cardiotoxic (−)

100%

Yes

(Value =0.3, limit=0.26)

Not applicable

 

Palmoxirate

Non-cardiotoxic (−)

60

No

(Value =0.21, limit=0.26)

Not applicable

 

Panalrestat

Non-cardiotoxic (−)

60

Yes

(Value =0.27, limit=0.26)

Not applicable

 

Phenformin

Potential cardiotoxic (+)

70

Yes

(Value =0.26, limit=0.26)

Strong/extreme

60

Pioglitazone

Potential cardiotoxic (+)

50

Yes

(Value =0.27, limit=0.26)

Weak/moderate

60

Pirogliride

Non-cardiotoxic (−)

50

Yes

(Value =0.24, limit=0.26)

Not applicable

 

Ranirestat

Potential cardiotoxic (+)

50

No

(Value =0.24, limit=0.26)

Weak/moderate

50

Remogliflozin

Potential cardiotoxic (+)

50

No

(Value =0.24, limit=0.26)

Weak/moderate

50

Repaglinide

Potential cardiotoxic (+)

50

Yes

(Value =0.31, limit=0.26)

Weak/moderate

60

Rivoglitazone

Non-cardiotoxic (-)

 

Yes

(Value =0.29, limit=0.26)

 

Not applicable

 

Rosiglitazone

Potential cardiotoxic (+)

50

Yes

(Value =0.28, limit=0.26)

Weak/moderate

60

Salfredin

Non-cardiotoxic (−)

70%

No

(Value =0.22, limit=0.26)

Not applicable

 

Saxagliptin

Non-cardiotoxic (−)

80

No

(Value =0.19, limit=0.26)

Not applicable

 

Sergliflozin

Potential cardiotoxic (+)

50

Yes

(Value =0.28, limit=0.26)

Weak/moderate

50

Sitagliptin

Non-cardiotoxic (−)

90

Yes

(Value =0.32, limit=0.26)

Not applicable

 

Sorbinil

Non-cardiotoxic (−)

60

No

(Value =0.25, limit=0.26)

Not applicable

 

Sotagliflozin

Potential cardiotoxic (+)

70

Yes

(Value =0.29, limit=0.26)

Weak/moderate

50

Sulfanilamide

Non-cardiotoxic (−)

80

No

(Value =0.21, limit=0.26)

Not applicable

 

Sulfisoxazole

Non-cardiotoxic (−)

70

No

(Value =0.24, limit=0.26)

 

Not applicable

 

Teneligliptin

Potential cardiotoxic (+)

50

No

(Value =0.25, limit=0.26)

Weak/moderate

50

Tofogliflozin

Potential cardiotoxic (+)

70

No

(Value =0.22, limit=0.26)

Strong/extreme

50

Tolazamide

Non-cardiotoxic (−)

70

Yes

(Value =0.34, limit=0.26)

Not applicable

 

Tolrestat

Potential cardiotoxic (+)

50

Yes

(Value =0.28, limit=0.26)

Weak/moderate

70

Tolbutamide

Non-cardiotoxic (−)

70

Yes

(Value =0.29, limit=0.26)

Not applicable

 

Trelagliptin

Potential cardiotoxic (+)

50

Yes

(Value =0.36, limit=0.26)

Weak/moderate

60

Vildagliptin

Non-cardiotoxic (−)

70

No

(Value =0.24, limit=0.26)

Not applicable

 

Troglitazone

Potential cardiotoxic (+)

60

No

(Value =0.24, limit=0.26)

Weak/moderate

50

Zenarestat

Non-cardiotoxic (−)

 

No

(Value =0.24, limit=0.26)

Not applicable

 

Voglibose

Non-cardiotoxic (−)

60

No

(Value =0.17, limit=0.26)

Not applicable

 

Zopolrestat

Non-cardiotoxic (−)

50

No

(Value =0.28, limit=0.26)

Not applicable

 
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