Demographics, clinical features, and prognosis of rare lymphoepithelioma-like carcinoma across different anatomic sites

Zhai, Xiaoqian; Liu, Jiewei; Lu, Donghao; Zhou, Qinghua

doi:10.1186/s43046-021-00103-2

Journal of the Egyptian National Cancer Institute

Table 1 Demographics and clinic features of patients with LELC according to tumor site

From: Demographics, clinical features, and prognosis of rare lymphoepithelioma-like carcinoma across different anatomic sites

Site	Nasopharynx		Salivary gland		Tonsil		Tongue		Nose, nasal cavity, and middle ear		Lung and bronchus		Urinary bladder		Female genital system		Digestive system
Number/percentage	1208	58%	167	8%	139	7%	58	3%	41	2%	86	4%	61	3%	52	2%	39	2%
Variable	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
Age of diagnosis
Mean age	47.6		60.5		49		55		61		63.2		69		49.6		68
≤ 65	1024	84.8	95	56.9	113	81.3	39	67.2	24	58.5	47	54.7	23	37.7	48	92.3	17	43.6
> 65	184	15.2	72	43.1	26	18.7	19	32.8	17	41.5	39	45.3	38	62.3	4	7.7	22	56.4
Sex
Male	867	71.8	79	47.3	101	72.7	47	81	28	68.3	45	52.3	41	67.2	0	0	29	74.4
Female	341	28.2	88	53.7	38	27.3	11	19	13	31.7	41	47.7	20	32.8	52	100	10	25.6
Race
White	512	42.4	105	62.9	122	87.8	52	89.6	25	61	52	60.5	52	85.3	40	76.9	31	80
Black	132	10.9	9	5.4	8	5.8	3	5.2	3	7.3	6	7	6	9.8	5	9.6	< 3	5
Asian or Pacific Islander	537	44.5	38	22.8	7	5	3	5.2	11	26.9	28	32.5	3	4.9	7	13.5	6	15
Tumor grade^a
Low (1–2)	4	0.5	6	6.7	3	2.7	0	0	0	0	< 3	1.8	< 3	1.9	3	6.8	< 3	3.2
High (3–4)	802	99.5	83	93.3	109	97.3	40	100	21	100	54	98.2	53	98.1	41	93.2	30	96.8
Tumor stage
Localized	120	14.5	64	38.3	14	10.1	5	8.6	3	10.7	35	42.2	12	19.7	32	64	22	56.4
Regional	551	66.6	76	45.5	113	81.3	46	79.3	23	82.1	33	39.7	40	65.6	16	32	13	33.3
Distant	102	12.3	21	12.6	10	7.2	4	6.9	< 3	7.2	14	16.9	8	13.1	< 3	< 3	3	7.7
Unknown	55	6.6	6	3.6	< 3	1.4	3	5.2	0	0	< 3	1.2	< 3	1.6	< 3	2	< 3	2.6
Tumor size
≤ 2cm	91	23.5	35	27.1	28	36.8	16	44.4	< 3	10	26	35.1	6	15.4	19	44.2	3	8.6
2–5cm	245	63.5	78	60.5	48	63.2	18	50	7	70	36	48.7	20	51.3	14	32.5	16	45.7
> 5cm	50	13	16	12.4	0	0	< 3	5.6	< 3	20	12	16.2	13	33.3	10	23.3	16	45.7
Nodes positive^b
Yes	306	33.4	65	43.1	63	55.3	21	42.9	3	13	21	25.6	8	13.1	10	19.2	9	23.7
No	610	66.6	86	56.9	51	44.7	28	57.1	20	87	61	74.4	53	86.9	42	80.8	29	76.3
Treatment	1208		167		139		58		41		86		61		52		39
Surg^c	242	20	151	90.4	85	61.2	23	39.7	15	36.6	62	72.1	57	93.4	48	92.3	31	79.5
Non-surg	966	80	16	9.6	54	38.8	35	60.3	26	63.4	24	27.9	4	6.6	4	7.7	8	20.5
Non-chemo	484	40	138	82.6	65	46.8	33	56.9	23	56	48	55.8	29	47.5	36	69.2	28	71.8
Chemo	724	60	29	17.4	74	53.2	25	43.1	18	44	38	44.2	32	52.5	16	30.8	11	28.2
XRT	1078	89.2	113	67.7	117	84.2	51	87.9	33	80.5	20	23.3	5	8.2	22	42.3	10	25.6
Non-XRT	130	10.8	54	32.3	22	15.8	7	12.1	8	19.5	66	76.7	56	91.8	30	57.7	29	74.4

Abbreviations: Surg surgery, XRT radiation therapy, Chemo chemotherapy
^aGrade: grade 1, well differentiated; grade 2, moderately differentiated; grade 3, poorly differentiated; grade 4, undifferentiated; anaplastic
^bNodes positive is only available after 1988
^cSurgery is only available after 1998

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