Fig. 1

Observed toxicities within the 120 cycles of HDMTX infusions in descending order of frequency. Figure 1 shows the distribution of the observed toxicities within the 120 cycles of HDMTX infusions in descending order of frequency. The most common observed toxicities were hematological toxicities (neutropenia and anemia) that were present in 77% of cycles, each. Oral mucositis came next in frequency 37%, followed by increased creatinine 33%, then thrombocytopenia 31%. Increased ALT, increased AST, and febrile neutropenia were present in 28%, 28%, and 26% of cycles, respectively. Vomiting was reported in 18% of cycles. Increased total bilirubin was present in 8% of cycles. Also, abdominal pain and diarrhea were observed in 6% of cycles. Conjunctivitis was present in 3% of cycles. The least frequently reported toxicities were upper gastrointestinal hemorrhage, maculopapular rash, and peripheral neuropathy (1%) of cycles