Table 4 Univariate survival analysis for PFS and OS using Kaplan-Meier Analysis (n=34)
Progression-free survival | Overall survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|
12 months | 24 months | 12 months | 24 months | ||||||
Parameters | Disease relapsed | Log rank P value | Disease relapsed | Log rank P value | Patients died | Log rank P value | Patients died | Log rank P value | |
N | N (%) | N (%) | |||||||
Age | |||||||||
≤50 | 16 | 02 (13) | 4.28 0.038 | 06 (38) | 7.52 0.006 | 01 (06) | 3.72 0.050 | 07 (44) | 9.51 0.002 |
>50 | 18 | 08 (45) | 14 (78) | 06 (33) | 16 (89) | ||||
Tumor Locations | |||||||||
Frontal | 12 | 03 (25) | NSa | 05 (42) | 9.38 0.025 | 02 (17) | NS | 06 (50) | 11.92 0.008 |
Temporal | 08 | 05 (63) | 07 (88) | 03 (38) | 08 (100) | ||||
Parietal | 12 | 02 (17) | 07 (58) | 02 (17) | 08 (67) | ||||
Occipital | 02 | 00 (00) | 01 (50) | 00 (00) | 01 (50) | ||||
KPSb Scale | |||||||||
High >60 | 18 | 02 (11) | 6.35 0.012 | 07 (39) | 9.57 0.002 | 01 (06) | 5.13 0.024 | 10 (56) | 6.88 0.009 |
Low <60 | 16 | 08 (50) | 13 (81) | 06 (38) | 13 (81) | ||||
IDH½ mutation status | |||||||||
Absent | 19 | 10 (53) | 10.63 0.001 | 13 (68) | 4.58 0.032 | 07 (37) | 8.11 0.017 | 14 (74) | NS |
Present | 15 | 00 (00) | 07 (47) | 00 (00) | 09 (60) | ||||
STAT3 gene expression | |||||||||
Normal expression | 05 | 01 (20) | 9.042 0.011 | 04 (80) | NS | 01 (20) | NS | 04 (80) | 4.39 0.036 |
Down regulation | 14 | 08 (57) | 09 (64) | 06 (43) | 10 (71) | ||||
Up regulation | 15 | 01 (07) | 07 (47) | 00 (00) | 09 (60) | ||||
High STAT3 & Mutant IDH together | |||||||||
Both are absent | 15 | 08 (53) | 6.44 0.011 | 11 (73) | 4.73 0.030 | 05 (33) | 9.67 | 12 (80) | 6.38 0.005 |
Any one is present | 19 | 02 (11) | 09 (47) | 02 (11) | 0.002 | 11 (58) | |||