Table 3 Association of EGFR 15 bp deletion in exon 19 with different variables of thyroid cancer patients
Variable | Cases n = 60 | EGFR 15 bp deletion in exon 19 (n = 60) | OR (95% CI) | P value | |
|---|---|---|---|---|---|
Positive n = 32 (53.3%) | Negative n = 28 (46.7%) | ||||
Gender |  |  |  | 1.6(0.5–5.3) | 0.39 |
 Female | 44(73.0) | 22(50.0) | 22(50.0) |  |  |
 Male | 16(27.0) | 10(62.5) | 06(37.5) |  |  |
Age in years |  |  |  | 0.7(0.2–2.2) | 0.55 |
 < 45 | 45(75.0) | 25(55.5) | 20(44.4) |  |  |
 ≥ 45 | 15(25.0) | 07(46.6) | 08(53.4) |  |  |
Habitation |  |  |  | 3.6(0.6–19.2) | 0.15 |
 Rural | 51(85.0) | 25(78.1) | 26(50.9) |  |  |
 Urban | 09(15.0) | 07(21.8) | 02(22.2) |  |  |
Marital status |  |  |  | 1.9(0.6–5.9) | 0.02* |
 Unmarried | 25(41.6) | 09(36.0) | 16(64.0) |  |  |
 Married | 35(53.4) | 23(65.7) | 12(34.3) |  |  |
Use of OCP |  |  |  | 0.7(0.1–4.8) | 0.25 |
 Yes | 05(8.4) | 03(60.0) | 02(40.0) |  |  |
 No | 55(91.6) | 29(52.7) | 26(47.3) |  |  |
Smoking status |  |  |  | 4.3(0.8–22.4) | 0.08 |
 Non-smoker | 50(83.4) | 24(48.0) | 26(52.0) |  |  |
 Smoker | 10(16.6) | 08(80.0) | 02(20.0) |  |  |
TSH levels |  |  |  | 0.1(0.04–0.45) | < 0.001* |
 Elevated | 27(45.0) | 21(77.7) | 06(22.3) |  |  |
 Normal | 33(55.0) | 11(33.3) | 22(66.7) |  |  |
Serum calcium |  |  |  | 1.5(0.5–4.4) | 0.46 |
 Normal | 40(66.6) | 20(50.0) | 20(50.0) |  |  |
 Decreased | 20(33.4) | 12(60.0) | 08(40.0) |  |  |
Initial PPX |  |  |  | 0.5(0.08–3.5) | 0.65 |
 Swelling | 55(91.6) | 30(54.5) | 25(45.4) |  |  |
 Incidental detection | 05(8.4) | 02(40.0) | 03(60.0) |  |  |
BTD |  |  |  | 0.7(0.1–4.8) | 0.25 |
 Yes | 05(80.0) | 03(60.0) | 02(40.0) |  |  |
 No | 55(20.0) | 29(52.7) | 26(47.3) |  |  |
Histological types |  |  |  | 0.2(0.05–.09) | 0.04* |
 Papillary | 48(80.0) | 29(60.5) | 19(39.5) |  |  |
 Follicular | 12(20.0) | 3(25.0) | 09(75.0) |  |  |
Grade |  |  |  | 2.5(0.7–7.8) | 0.11 |
 WD | 41(68.4) | 19(46.3) | 22(53.7) |  |  |
 PD | 19(31.6) | 13(68.4) | 06(31.6) |  |  |
Stage, < 45 years |  |  |  | 1.8(0.5–6.3) | 0.33 |
 Stage I | 28(46.6) | 14(50.0) | 14(50.0) |  |  |
 Stage II | 17(28.4) | 11(64.7) | 06(35.3) |  |  |
Stage, ≥ 45 years |  |  |  | 0.4(0.04–3.4) | 0.60 |
 Stage I and II | 09(15.0) | 05(55.5) | 04(44.5) |  |  |
 Stage III and above | 06(10.0) | 02(33.3) | 04(66.7) |  |  |
V/C invasion |  |  |  | 1.3(0.5–3.6) | 0.58 |
 Present | 32(53.4) | 16(50.0) | 16(50.0) |  |  |
 Absent | 28(46.6) | 16(57.1) | 12(42.9) |  |  |
LN metastasis |  |  |  | 2.8(0.9–9.0) | 0.07 |
 Present | 17(28.4) | 06(35.2) | 11(64.8) |  |  |
 Absent | 43(71.6) | 26(60.4) | 17(39.6) |  |  |