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Journal of the Egyptian National Cancer Institute
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  1. We previously reported that in highly metastatic breast cancer cells, doxorubicin (DOX) at non-toxic concentrations promoted cell migration and invasion. Hesperidin (30, 5, 9-dihydroxy-40-methoxy-7-orutinosyl ...

    Authors: Nur Dina Amalina, Irfani Aura Salsabila, Ummi Maryam Zulfin, Riris Istighfari Jenie and Edy Meiyanto
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:6
    Content type: Research Published on:

  2. Multi-parametric magnetic resonance imaging may improve the detection of prostate cancer. The aim of this work is to compare between PI-RADS 3–5 and PI-RADS 4–5 as a threshold for targeted prostatic biopsy.

    Authors: Hesham Abdel-Azim El-Helaly, Asem Abdel-Aziz Mahmoud, Ahmed Mohamed Magdy, Abdelwahab Hasehem, Hamdy Mohamed Ibrahim, Khaled Moheyelden Mohamed and Mohamed Hamdy Ismail
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:5
    Content type: Research Published on:

  3. Radiotherapy (RT) is an important part of the treatment of many tumors. Radiotherapy causes oxidative damage in all cellular compartments, including lipid membrane, on a random basis. Toxic lipid peroxidation ...

    Authors: Sanaa A. El-Benhawy, Ibrahim G. Abdelrhman, Nadia A. Sadek, Enayat I. Fahmy, Ahmed A. AboGabal, Hossam Elmasry, Sally A. M. Saleh, Ola A. Sakr, Mona Nagy Elwany and Maha Abubakr Feissal Rabie
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:4
    Content type: Research Published on:

  4. Laryngeal cancer is the ninth commonest cancer among Asian males. Global and regional epidemiological analyses have shown varying patterns in the incidence and risk factors for laryngeal cancer. Therefore, we ...

    Authors: Umesh Jayarajah, Ravindri Jayasinghe, Ashan Fernando and Sanjeewa Seneviratne
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:3
    Content type: Research Published on:

  5. Childhood parotid neoplasms appear to have different characteristics from adults. This point, in addition to the rarity of these tumors, reflects the challenges faced in diagnosing and treating parotid neoplas...

    Authors: Alaa Younes, Mohammad Fouad Taher, Iman Sidhom, Wael Zekri, Iman Zaky, Habiba Elfendy, Azza Niazy Taher, Suzan Adlan Khedr, Rana Gamal and Gehad Ahmed
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:2
    Content type: Research Published on:

  6. The prevalence of head and neck cancer (HNC) is increasing rapidly, and the prognosis is poor in the advance stage. For the patient suffering from advance stage HNC, the improvement in quality of life and decr...

    Authors: Avinash Khadela, Bhavin Vyas, Mustakim Mansuri, Dipen Sureja and Kunjan Bodiwala
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:1
    Content type: Research Published on:

  7. Biological response modifiers (immunotherapy) in combination to chemotherapy are superior to that of chemotherapy in treatment of breast cancer (triple-negative/HER-2 ( +)), multiple myeloma, and non-small-cel...

    Authors: William Morse, Haroon Nawaz and Ayesha A. Choudhry
    Citation: Journal of the Egyptian National Cancer Institute 2023 34:58
    Content type: Review Published on:

  8. The theme of the St. Gallen International Breast Cancer Conference 2021 held virtually for the first time, due to the COVID-19 pandemic, was on tailoring therapies for patients with early breast cancer. A monk...

    Authors: Hussein Khaled, Yousry Wasef Nada, Kareem Mohamed Ramadan, Shawkat Fekry, Mohamed Samy Seleam, Rabab Gaafar and Mohamed Lotayef
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:56
    Content type: Research Published on:

  9. Gastric cancer (GC) ranks second in mortality among all malignant diseases worldwide. However, the cause and molecular mechanism underlying gastric cancer are not clear. Here, we used integrated bioinformatics...

    Authors: Shuanhu Wang, Song Tao, Yakui Liu, Yi Shi and Mulin Liu
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:55
    Content type: Research Published on:

  10. The bladder cancer (BC) pathology is caused by both exogenous environmental and endogenous molecular factors. Several genes have been implicated, but the molecular pathogenesis of BC and its subtypes remains d...

    Authors: Güldal Inal Gültekin, Özlem Timirci Kahraman, Murat Işbilen, Saliha Durmuş, Tunahan Çakir, İlhan Yaylim and Turgay Isbir
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:54
    Content type: Research Published on:

  11. Gastric adenocarcinoma is one of the most aggressive forms of cancer. Despite marked advancements in radiological techniques, peritoneal deposits are still only discovered during laparotomies in a significant ...

    Authors: Mohamed Atef ElKordy, Rady Mansour Soliman, Mahitab Ibrahim ElTohamy, Dalia Negm Eldin Mohamed and Ahmed Morsi Mustafa
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:53
    Content type: Research Published on:

  12. Mature B-cell non-Hodgkin lymphomas are one of the most common hematological malignancies with a divergent clinical presentation, phenotype, and course of disease regulated by underlying genetic mechanism.

    Authors: Devasis Panda, Nupur Das, Deepshi Thakral and Ritu Gupta
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:52
    Content type: Review Published on:

  13. Mammosphere formation assay has become a versatile tool to quantify the activity of putative breast cancer stem cells in non-adherent in vitro cultures. However, optimizing the suspension culture system is cru...

    Authors: Jenifer Mallavarpu Ambrose, Vishnu Priya Veeraraghavan, Rosy Vennila, Secunda Rupert, Jeswanth Sathyanesan, Rajasundari Meenakshisundaram, Sakthivel Selvaraj, Sarubala Malayaperumal, Malathi Kullappan, Sudarsanam Dorairaj, Jayesh R. Gujarathi, Sri Harshini Gandhamaneni and Krishna Mohan Surapaneni
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:51
    Content type: Research Published on:

  14. Colorectal cancer (CRC) is one of the most important cancers in the world, and its prevalence varies depending on the geographical area. Genetically, tumor regeneration in CRC as a multi-step process involves ...

    Authors: Hoora Naebi, Ahmadreza Bandegi, Fereshteh Talebinasab, Pirouz Samidoust, Seyedeh Elham Norollahi, Sogand Vahidi and Ali Akbar Samadani
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:57
    Content type: Research Published on:

  15. Breast cancer screening can reduce mortality and improve the quality of life in affected women. The present study aimed to determine the predictive factors of breast cancer screening in Iranian women based on ...

    Authors: Narjes Bahri, Fariba Mardani, Neda Sharifi and Sareh Dashti
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:50
    Content type: Systematic Review Published on:

  16. Ipsilateral synchronous renal and ureteric tumor is uncommon. Nephron sparing surgery is the standard for small renal masses. Ureteric tumors can be selectively managed with nephron sparing surgery, especially...

    Authors: Anandan Murugesan
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:49
    Content type: Case Reports Published on:

  17. Surgical resection is the primary treatment for advanced-stage heterotopic ossification (HO), with a high incidence of local recurrence reaching up to 50%. Postoperative radiotherapy (PORT) and indomethacin ar...

    Authors: Reham Mohamed, Asif Iqbal and Abosaleh Abosaleh Elawadi
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:48
    Content type: Research Published on:

  18. Urothelial carcinomas (UC) can be either in the upper or in the lower urinary tract or both. Urothelial bladder cancer (UBC) is more common than upper tract urothelial carcinoma (UTUC). This research was desig...

    Authors: Eman E. Dawood, Amira Awadalla, Abdelwahab Hashem, Ahmed A. Shokeir and A. F. Abdel-Aziz
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:47
    Content type: Research Published on:

  19. The reported incidence of leptomeningeal carcinomatosis is 3–8% in patients with solid tumours. More commonly, it has been described in the setting of advanced cancers of the lung, breast and malignant melanoma.

    Authors: Jhansi Pattanaik, Varshu Goel, Priyanka Sehrawat, Ruchi Rathore, Rajesh Kumar Singh, Ajay Garg and Ahitagni Biswas
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:46
    Content type: Case Reports Published on:

  20. Brain metastases (BM) are associated with dismal prognosis as they cause significant morbidity and affect the quality of life of patients. Management of BM depends on the following factors: age, patient perfor...

    Authors: Sweety Gupta, Sumit Singh, Atokali Chophy, Sharanya Nair, Rachit Ahuja, K. Kusum, Deepa Joseph, Rajnish Arora, Amit Gupta and Manoj Gupta
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:45
    Content type: Research Published on:

  21. The conventional standard treatment for ovarian cancer is not very effective, and the disease is fatal for women. Cancer Stem Cells (CSCs) that express CD44+/CD24- can contribute to chemoresistance and a poor pro...

    Authors: Unedo Hence Markus Sihombing, Andrijono Andrijono, Gatot Purwoto, Supriadi Gandamihardja, Alida R. Harahap, Primariadewi Rustamadji, Aria Kekalih, Retno Widyawati and Dzicky Rifqi Fuady
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:44
    Content type: Research Published on:

  22. EGFR mutation has not been extensively studied in thyroid cancer. This study was conducted to study spectrum of EGFR mutation in thyroid cancer in Kashmiri population for possible therapeutic purpose.

    Authors: Tariq Ahmad Mir, Ajaz Qadir, Munir Ahmad Wani and Muzafar Maqsood Wani
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:43
    Content type: Research Published on:

  23. Endometrial cancer (EC) is a common malignant tumor in women with increasing mortality. The prognosis of EC is highly heterogeneous which needs more effective biomarkers for clinical decision. Here, we reporte...

    Authors: Shiyang Li, Junan Pan, Yanyu Zhang, Yan Tang, Xiaobing Zeng, Shihai Wang, Dengxuan Wu, Yuyong Liu, Dawen Xu, Jianjun Lan and Dong Hu
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:42
    Content type: Research Published on:

  25. Urothelial carcinoma (UC) is the most common type of bladder cancer. Glucose transporter 4 (GLUT4) is one of glucose transporter proteins’ family which facilitates glucose transport inside the cells. It was fo...

    Authors: Marwa A. Abd El-Azeem, Mona A. Ali and Safinaz H. El-Shorbagy
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:40
    Content type: Research Published on:

  26. High-grade transformation Adenoid cystic carcinoma (HGT-AdCC) of the parotid gland is a rare transformation noted in slow growing low grade AdCC. Perineural invasion and spread is an important feature of this ...

    Authors: Manu Coimbatore Balakrishnan, Abhijeet Bhatia, Bifica Sofia Lyngdoh, Caleb Harris, Donboklang Lynser and Pranjal Kalita
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:39
    Content type: Case Reports Published on:

  27. Preclinical studies prove that short-term fasting secures healthy cells against chemotherapy side effects and makes malignant cells more vulnerable to them. This study aimed to examine the effects of intermitt...

    Authors: Enas M. Omar, Gamal A. Omran, Mohamed F. Mustafa and Noha M. El-Khodary
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:38
    Content type: Research Published on:

  28. About 7 million people die from various types of cancer every year representing nearly 12.5% of deaths worldwide. This fact raises the demand to develop new, effective anticancer, onco-suppressive, and chemopr...

    Authors: Ahmed M. Hussein, Abdelraheim H. Attaai and Asmaa M. Zahran
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:37
    Content type: Research Published on:

  29. There are different types of malignant tumors that can affect the thyroid gland where differentiated thyroid carcinomas (papillary and follicular) are the most common representing nearly 90% of cases. Non-epit...

    Authors: Shadi Awny, Mohammad Zuhdy, Omar Hamdy, Gehad Ahmad Saleh, Ahmed Hassan, Mohamed Abdelkhalek, Amir Mosaad, Mohamed T. Hafez, Sameh Roshdy, Ahmed Setit and Nirmeen Megahed
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:36
    Content type: Case Reports Published on:

  30. Colorectal cancers (CRC) are among the most common cancers. There are different modalities for treatment including chemotherapy, surgery, and radiotherapy. There are some mutations in cancers which can assist ...

    Authors: Hasan Ashoori, Shaghayegh Kamian, Farnaz Vahidian and Mohammad Ebrahim Ghamarchehreh
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:35
    Content type: Research Published on:

  32. While majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new treatment modalities takes a significant period of research, time...

    Authors: Shafina Siddiqui, Ankita Jaywant Deshmukh, Priyanka Mudaliar, Apoorva Jagannath Nalawade, Deepak Iyer and Jyotirmoi Aich
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:33
    Content type: Review Published on:

  33. Due to the high prevalence of HIV, HIV-associated lymphoma (HAL) is a common malignancy in South Africa. However, there is a paucity of literature on HAL from this region. The objective of this study was to pr...

    Authors: Nadine Rapiti, Nada Abdelatif, Anand Rapiti and Mahomed-Yunus Moosa
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:32
    Content type: Research Published on:

  34. Metastatic breast cancer (MBC) is a major health problem worldwide. Some patients improve on tamoxifen and others do not respond to treatment. Therefore, the aim of the current study is to assess genetic aberr...

    Authors: Ibrahim Malash, Osman Mansour, Rabab Gaafar, Sabry Shaarawy, Mona S. Abdellateif, Ola S. Ahmed, Abdel-Rahman N. Zekri and Abeer Bahnassy
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:31
    Content type: Research Published on:

  35. Glioblastoma Multiforme (GBM), a devastating the most common primary malignant intracranial brain tumors. In India, the incidence of this malignancy is escalating, however, there are very few studies on this t...

    Authors: Trupti Trivedi, Kinjal Panchal, Neha Bhalala and Priti Trivedi
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:30
    Content type: Research Published on:

  36. One of the main limitations of radiation therapy is the resistance of tumor cells. This study aimed at evaluating the relationship between the expression of epidermal growth factor receptor (EGFR) and echinode...

    Authors: Nadeem M. S. Nagi, Yasir A. M. Khair, Khamis H. Bakari, Mohamed N. Nagi and Fabian P. Mghanga
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:29
    Content type: Research Published on:

  37. COVID-19 patients with cancer had poorer outcomes due to immunosuppression during cancer care, poor general condition, and other comorbidities. The study was conducted to present the real-world analysis of the...

    Authors: Sandip Kumar Barik, Arvind Kumar Singh, Minakshi Mishra, Adhar Amritt, Dinesh Prasad Sahu, Saroj Kumar Das Majumdar and Dillip Kumar Parida
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:28
    Content type: Research Published on:

  38. Sarcoma of unknown primary (SUP) designates an enigmatic entity with histologic confirmation of a metastatic tumor without an identifiable primary after a thorough diagnostic workup. The term “unknown primary”...

    Authors: Elie Rassy, Rosy Abou-Jaoude, Stergios Boussios, Tarek Assi, Joseph Kattan, Hussein Khaled and Nicholas Pavlidis
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:27
    Content type: Review Published on:

  40. The therapy design of childhood acute lymphoblastic leukemia (ALL) has evolved over the past 60 years. The St. Jude Children’s Research Hospital has developed 17 treatment protocols from 1962 to 2017, aiming t...

    Authors: Abdallah A. Omar, Lina Basiouny, Ahmed S. Elnoby, Abeer Zaki and Mohamed Abouzid
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:25
    Content type: Review Published on:

  42. Programmed death ligand-1 (PD-L1), anaplastic lymphoma kinase (ALK), and c-ros oncogene1 (ROS1) expression may influence the prognosis of non-small cell lung carcinoma (NSCLC). We aimed to investigate the prog...

    Authors: Abeer A. Bahnassy, Hoda Ismail, Marwa Mohanad, Ahmed El-Bastawisy and Hend F. Yousef
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:23
    Content type: Research Published on:

  43. The administration of 5-fluorouracil (5FU) in the treatment of gastrointestinal (GI) malignancies is associated with common side effects such as mucositis, diarrhoea, and myelosuppression, which are easily man...

    Authors: Neethu Jose, Anjana Joel, Rajesh Joseph Selvakumar, Jebakarunya Ramireddy, Ajoy Oommen John, Josh Thomas Georgy, Ashish Singh and Thomas Samuel Ram
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:22
    Content type: Research Published on:

  44. Multiple myeloma (MM) predominantly affects older patients; many of whom do not undergo autologous hematopoietic stem cell transplant (AHSCT) despite the associated survival benefits. This study was conceived ...

    Authors: Swaroop Revannasiddaiah, Prathap Raja Varma Muppalla Ayalgaraj Nagaraju, Rasmi Palassery, Apoorva Jagadish, Vinayak V. Maka, Nalini Kilara, Damiano Rondelli and Santhosh Kumar Devadas
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:21
    Content type: Research Published on:

  45. Treatment-related toxicities in DLBCL (diffuse large B cell lymphoma) patients are higher in the initial phase of treatment (first cycle effect). Implementation of pre-phase treatment before definitive chemoth...

    Authors: A. H. Rudresha, Syed Adil Hassan, A. Sreevalli, D. Lokanatha, M. C. Suresh Babu, K. N. Lokesh, L. K. Rajeev, Smitha Saldanha, Antony G. F. Thottian, Kanika Sharma and Linu Abraham Jacob
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:20
    Content type: Research Published on:

  46. Breast cancer is a fatal disease and a major reason of cancer associated death in females. Many factors along with miRNA are responsible for the development and the progression of the disease. The miRNA plays ...

    Authors: Apexa Raval, Jigna Joshi and Franky Shah
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:19
    Content type: Review Published on:

  47. Vascular endothelial growth factor A (VEGF-A) plays an integral role in angiogenesis by contributing to growth, development, and metastasis of solid tumors. Recently, a single-nucleotide polymorphism +936C/T l...

    Authors: Sai Sushmitha Kontham, Charles Emmanuel Jebaraj Walter, Zioni Sangeetha Shankaran, Arvind Ramanathan, Nirmala Karuppasamy and Thanka Johnson
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:18
    Content type: Meta-analysis Published on:

  48. Repeated high-dose methotrexate (HDMTX) is a critical component of contemporary childhood acute lymphoblastic leukemia (ALL) treatment regimens. Serum albumin is considered a carrier of methotrexate (MTX) in t...

    Authors: Shaimaa Barakat, Hala Assem, Mostafa Salama, Neveen Mikhael and Yasmine El Chazli
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:17
    Content type: Research Published on:

  49. Breast cancer (BC) is one of the most prevalent cancers in developing and developed countries among women worldwide. Mammography is one of the superior methods for BC detection, but it carries up to 20% false-...

    Authors: Mai Ali, Dina El Gayar, Normeen Hany, Abdel Hamid Ezzat and Reham Zeyada
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:16
    Content type: Research Published on:

  50. Hepatic resection (HR) for hepatocellular carcinoma (HCC) is safe with good perioperative and long-term oncologic outcomes. There is a paucity of data with regards to intermediate-term outcomes (i.e., beyond 9...

    Authors: Sanaa Sheriff, Sudharsan Madhavan, Geraldine Yanlei Lei, Yiong Huak Chan, Sameer P. Junnarkar, Cheong Wei Huey, Jee Keem Low and Vishal G. Shelat
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:14
    Content type: Research Published on:
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  • ISSN: 2589-0409 (electronic)