Skip to main content

Table 5 Univariate and multivariate Cox-regression analyses for overall and disease-free survival

From: Initial absolute monocyte count as an immune biomarker for clinical response in acute myeloid leukemia with monocytic differentiation

Covariates

Overall survival

Disease-free survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Age (> 60Y vs. ≤ 60Y)

0.80 (0.28–2.31)

0.682

  

0.04 (0.00–36.60)

0.35

  

Sex (M vs. F)

1.29 (0.63–2.66)

0.485

  

1.89 (0.58–6.23)

0.293

  

PS (> 1 Y vs. ≤ 1)

1.24 (0.50–3.04)

0.642

  

0.04 (0.00–23.31)

0.317

  

PIF (yes vs. no)

7.8 (3.2–19.2)

< 0.001

6.9 (2.7–17.9)

< 0.001

2.5 (0.52–11.92)

0.296

  

FAB (M4 vs. M5)

0.74 (0.36–1.52)

0.412

  

0.61 (0.19–1.98)

0.409

  

Intensive induction (yes vs. no)

0.64 (0.31–1.32)

0.226

  

4.83 (0.99–23.59)

0.052

6.98 (0.69–70.77)

0.1

Initial PB blast %

1.00 (0.99–1.02)

0.552

  

1.02 (1.00–1.04)

0.055

1.05 (0.99–1.10)

0.092

Initial BM blast %

1.00 (0.99–1.02)

0.693

  

1.00 (0.98–1.03)

0.797

  

Initial TLC × 109/L

1.00 (0.99–1.01)

0.989

  

1.02 (1.00–1.04)

0.058

  

Cytogenetics (favorable vs. others)

0.05 (0.00–56.25)

0.394

  

0.04 (0.00–36.60)

0.35

  

Monocytopenic (yes vs. no)

1.91 (0.90–4.04)

0.091

1.03 (0.46–2.34)

0.941

3.65 (1.22–10.93)

0.021

1.26 (0.10–15.43)

0.856

Initial PLT × 109/L

1.00 (1.00–1.01)

0.002

1.00 (0.99–1.04)

0.338

0.99 (0.97–1.01)

0.686

  

Initial Hb g/dL

1.03 (0.85–1.25)

0.75

  

1.06 (0.77–1.47)

0.715

  
  1. PS performance status, FAB French-American-British, PIF primary induction failure, BM bone marrow, PB peripheral blood, TLC total leucocytic count, Hb hemoglobin, PLT platelets, HR hazard ratio, 95%CI 95% confidence interval