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Journal of the Egyptian National Cancer Institute
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  1. Screening and early diagnosis of oral squamous cell carcinoma (OSCC) are directly associated with increased survival rate and improved prognosis. Noninvasive diagnostic tools have been implemented in the early...

    Authors: Alaa Elnaggar, Gihane Madkour, Neveen Tahoun, Ayman Amin and Fat’heya M. Zahran
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:31
    Content type: Research Published on:

  2. Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mis...

    Authors: Hatem Wael Amer, Hana’a Hezam Algadi and Shyma’a Ahmed Hamza
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:30
    Content type: Case Reports Published on:

  3. Hodgkin lymphoma (HL) is a highly curable malignant tumor. Risk-adapted treatment for children with HL aims to maximize survival while minimizing toxicity. The purpose of this study is to evaluate the outcome ...

    Authors: Nesreen Ali, Mohamed Mansour, Ehab Khalil and Emad Ebeid
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:29
    Content type: Research Published on:

  4. Breast cancer is the most common tumor among women throughout the world. Diagnosis and treatment of breast cancer are associated with stress and depression. Self-efficacy is one of the most important personal ...

    Authors: Azza El-Amir, Eman M. El-Baiomy, Noha A. Sabry, Loay Kassem, Margaret A. Chesney and Kenneth A. Wallston
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:28
    Content type: Research Published on:

  5. Hypoxia arises due to insufficient oxygen delivery to rapidly proliferating tumour cells that outpace the available blood supply. It is a characteristic feature of most solid tumour microenvironments and plays...

    Authors: Shinjini Bandopadhyay and Somi Patranabis
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:27
    Content type: Review Published on:

  6. Both S100A4 and Glypican-3 have been known to be engaged in HCC development and progression. This study aimed to evaluate both S100A4 and GPC3 expression in HCC tissues as a prognostic markers.

    Authors: Mahmoud El-Bendary, Khaled Farid, Mohammad Arafa, Wagdi Elkashef, Talaat Abdullah and Ahmed El-Mesery
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:26
    Content type: Research Published on:

  7. The huge number of detected somatic KIT mutations highlights the necessity of in silico analyses that are almost absent in the relevant medical literature. The aim of this study is to report the mutation spectrum...

    Authors: Nour Pharaon, Wafa Habbal and Fawza Monem
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:25
    Content type: Research Published on:

  8. Breast cancer is the most common tumor among females globally. Its prevalence is growing around the world, and it is alleged to be the leading cause of cancer death. Approved anti-breast cancer drugs display s...

    Authors: Sagiru Hamza Abdullahi, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba and Abdullahi Bello Umar
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:24
    Content type: Research Published on:

  9. Immunohistochemical expression of P53 protein is so closely related to status of mutation of P53 gene which is tightly linked with pathogenesis of nephroblastoma or Wilms tumor. This study aims to determine th...

    Authors: Emmanuel D. Morgan, James J. Yahaya, Advera I. Ngaiza, Emmanuel Othieno and Okwi A. Livex
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:23
    Content type: Research Published on:

  10. Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. GBM patients usually have a poor prognosis. Identification of genes associated with the progression of the dis...

    Authors: Seema Sandeep Redekar, Satishkumar L. Varma and Atanu Bhattacharjee
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:22
    Content type: Research Published on:

  11. The purpose of this study was to assess the usefulness of fluorodeoxyglucose positron emission tomography (18F-FDG PET)-computed tomography (CT) scan for staging urinary bladder cancer. The study also sought to d...

    Authors: Mohammed Shahait, Ramiz Abu-Hijlih, Ala’a Farkouh, Shahed Obeidat, Samer Salah, Ahmed Saad Abdlkadir and Akram Al-Ibraheem
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:21
    Content type: Research Published on:

  12. In the Ugandan setting, investigation for PHNM with CT uses a protocol with both unenhanced and contrast enhanced procedures hence doubling the ionizing radiation exposure. The purpose of this study was to det...

    Authors: Alex Mwesigwa Mugisha, Zeridah Muyinda, Joyce Balagadde Kambugu, Denise Apolot, Elizabeth Atugonza, Anneth Teu and Aloysius Gonzaga Mubuuke
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:20
    Content type: Research Published on:

  14. Acute lymphoblastic leukemia (ALL) is a malignancy that leads to altered blast cell proliferation, survival, and maturation and eventually to the lethal accumulation of leukemic cells. Recently, dysregulated e...

    Authors: Mahdiyar Iravani Saadi, Mohsen Nikandish, Zahra Ghahramani, Fatemeh Mardani Valandani, Maryam Ahmadyan, Fakhroddin Hosseini, Zahra Rahimian, Heeva Jalali, Fataneh Tavasolian, Ehsan Nabi Abdolyousefi, Nadiya Kheradmand and Mani Ramzi
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:18
    Content type: Research Published on:

  15. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few accepted prognostic factors that limit the efficiency of therapy. The aim of the current study was to assess the clinical and la...

    Authors: Mona S. El Ashry, Enas Radwan, Mona S. Abdellateif, Omar Arafah and Naglaa M. Hassan
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:17
    Content type: Research Published on:

  16. Metaplastic breast cancer (MetBC) still represents a conundrum owing to its peculiar histogenesis and molecular drivers that render it extremely resistant to standard chemotherapy with ultimate dismal survival.

    Authors: Yahia Ismail, Amr Kamal, Rasha Allam and Al-Shimaa Zakaria
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:16
    Content type: Research Published on:

  17. A malignancy of the endocrine system, one of the most common types, is thyroid cancer. It is proven that children who receive radiation treatment for leukemia or lymphoma are at a heightened risk of thyroid ca...

    Authors: Iyshwarya Bhaskar Kalarani, Ganesan Sivamani and Ramakrishnan Veerabathiran
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:15
    Content type: Review Published on:

  18. Breast cancer is the most common female cancer worldwide. Its diagnosis and prognosis remain scanty, imprecise, and poorly documented. Previous studies have indicated that some genetic mutational signatures ar...

    Authors: Patrick Odhiambo, Harrison Okello, Annette Wakaanya, Clabe Wekesa and Patrick Okoth
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:14
    Content type: Research Published on:

  19. The prognostic value of the level of programmed death ligand 1 (PD-L1) expression in non-Hodgkin lymphoma (NHL) is still debatable. This study examined the effect of the level of PD-L1 expression on the clinic...

    Authors: Eman Mohamad Ibrahim, Sherine Refat, Shaimaa El-Ashwah, Maryan Waheeb Fahmi and Afaf Taha Ibrahiem
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:12
    Content type: Research Published on:

  20. Neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) became the standard of care for muscle-invasive bladder cancer (MIBC) in the last few years. We aimed to evaluate the radiological, pathological re...

    Authors: Ibrahim Abdelrahman, Hatem Aboulkassem, Abdallah Elazab, Ahmed Younis Abdallah, Yahia Ismail and Mohammad Taher
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:13
    Content type: Research Published on:

  21. This study was performed to investigate the expression of different biomarkers in patients with hepatocellular carcinoma and its connection with detective biomarkers. To achieve this objective, seventy subject...

    Authors: Ahmed Daif, Mahmood A. Al-Azzawi, Moustafa A. Sakr, Hisham A. Ismail and Mahmoud Gadallah
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:11
    Content type: Research Published on:

  23. Health-related quality of life has emerged as a significant component in pediatric oncology research during the last several decades. Measures of health-related quality of life provide a thorough assessment of...

    Authors: Mai Sabry Saleh, Asmaa Mahmoud Mohammed, Dina Bassiouni, Hend Helmy Mostafa and Zeinab Mohammed Monir
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:9
    Content type: Research Published on:

  24. Gastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment o...

    Authors: Mousa Fadaei, Maryam Kohansal, Omidreza Akbarpour, Mahsa Sami and Ali Ghanbariasad
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:8
    Content type: Research Published on:

  25. Driver molecular aberrations, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement, play an important role in the oncogenesis and progression of non-squ...

    Authors: Mohamed Said Ismail, Loay Kassem, Ahmed Al-Husseiny Ali, Fatma Elzahraa Ahmed, Mohamed Shalaby and Sally Magdy
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:7
    Content type: Research Published on:

  26. We previously reported that in highly metastatic breast cancer cells, doxorubicin (DOX) at non-toxic concentrations promoted cell migration and invasion. Hesperidin (30, 5, 9-dihydroxy-40-methoxy-7-orutinosyl ...

    Authors: Nur Dina Amalina, Irfani Aura Salsabila, Ummi Maryam Zulfin, Riris Istighfari Jenie and Edy Meiyanto
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:6
    Content type: Research Published on:

  27. Multi-parametric magnetic resonance imaging may improve the detection of prostate cancer. The aim of this work is to compare between PI-RADS 3–5 and PI-RADS 4–5 as a threshold for targeted prostatic biopsy.

    Authors: Hesham Abdel-Azim El-Helaly, Asem Abdel-Aziz Mahmoud, Ahmed Mohamed Magdy, Abdelwahab Hasehem, Hamdy Mohamed Ibrahim, Khaled Moheyelden Mohamed and Mohamed Hamdy Ismail
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:5
    Content type: Research Published on:

  28. Radiotherapy (RT) is an important part of the treatment of many tumors. Radiotherapy causes oxidative damage in all cellular compartments, including lipid membrane, on a random basis. Toxic lipid peroxidation ...

    Authors: Sanaa A. El-Benhawy, Ibrahim G. Abdelrhman, Nadia A. Sadek, Enayat I. Fahmy, Ahmed A. AboGabal, Hossam Elmasry, Sally A. M. Saleh, Ola A. Sakr, Mona Nagy Elwany and Maha Abubakr Feissal Rabie
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:4
    Content type: Research Published on:

  29. Laryngeal cancer is the ninth commonest cancer among Asian males. Global and regional epidemiological analyses have shown varying patterns in the incidence and risk factors for laryngeal cancer. Therefore, we ...

    Authors: Umesh Jayarajah, Ravindri Jayasinghe, Ashan Fernando and Sanjeewa Seneviratne
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:3
    Content type: Research Published on:

  30. Childhood parotid neoplasms appear to have different characteristics from adults. This point, in addition to the rarity of these tumors, reflects the challenges faced in diagnosing and treating parotid neoplas...

    Authors: Alaa Younes, Mohammad Fouad Taher, Iman Sidhom, Wael Zekri, Iman Zaky, Habiba Elfendy, Azza Niazy Taher, Suzan Adlan Khedr, Rana Gamal and Gehad Ahmed
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:2
    Content type: Research Published on:

  31. The prevalence of head and neck cancer (HNC) is increasing rapidly, and the prognosis is poor in the advance stage. For the patient suffering from advance stage HNC, the improvement in quality of life and decr...

    Authors: Avinash Khadela, Bhavin Vyas, Mustakim Mansuri, Dipen Sureja and Kunjan Bodiwala
    Citation: Journal of the Egyptian National Cancer Institute 2023 35:1
    Content type: Research Published on:

  32. Biological response modifiers (immunotherapy) in combination to chemotherapy are superior to that of chemotherapy in treatment of breast cancer (triple-negative/HER-2 ( +)), multiple myeloma, and non-small-cel...

    Authors: William Morse, Haroon Nawaz and Ayesha A. Choudhry
    Citation: Journal of the Egyptian National Cancer Institute 2023 34:58
    Content type: Review Published on:

  33. The theme of the St. Gallen International Breast Cancer Conference 2021 held virtually for the first time, due to the COVID-19 pandemic, was on tailoring therapies for patients with early breast cancer. A monk...

    Authors: Hussein Khaled, Yousry Wasef Nada, Kareem Mohamed Ramadan, Shawkat Fekry, Mohamed Samy Seleam, Rabab Gaafar and Mohamed Lotayef
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:56
    Content type: Research Published on:

  34. Gastric cancer (GC) ranks second in mortality among all malignant diseases worldwide. However, the cause and molecular mechanism underlying gastric cancer are not clear. Here, we used integrated bioinformatics...

    Authors: Shuanhu Wang, Song Tao, Yakui Liu, Yi Shi and Mulin Liu
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:55
    Content type: Research Published on:

  35. The bladder cancer (BC) pathology is caused by both exogenous environmental and endogenous molecular factors. Several genes have been implicated, but the molecular pathogenesis of BC and its subtypes remains d...

    Authors: Güldal Inal Gültekin, Özlem Timirci Kahraman, Murat Işbilen, Saliha Durmuş, Tunahan Çakir, İlhan Yaylim and Turgay Isbir
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:54
    Content type: Research Published on:

  36. Gastric adenocarcinoma is one of the most aggressive forms of cancer. Despite marked advancements in radiological techniques, peritoneal deposits are still only discovered during laparotomies in a significant ...

    Authors: Mohamed Atef ElKordy, Rady Mansour Soliman, Mahitab Ibrahim ElTohamy, Dalia Negm Eldin Mohamed and Ahmed Morsi Mustafa
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:53
    Content type: Research Published on:

  37. Mature B-cell non-Hodgkin lymphomas are one of the most common hematological malignancies with a divergent clinical presentation, phenotype, and course of disease regulated by underlying genetic mechanism.

    Authors: Devasis Panda, Nupur Das, Deepshi Thakral and Ritu Gupta
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:52
    Content type: Review Published on:

  38. Mammosphere formation assay has become a versatile tool to quantify the activity of putative breast cancer stem cells in non-adherent in vitro cultures. However, optimizing the suspension culture system is cru...

    Authors: Jenifer Mallavarpu Ambrose, Vishnu Priya Veeraraghavan, Rosy Vennila, Secunda Rupert, Jeswanth Sathyanesan, Rajasundari Meenakshisundaram, Sakthivel Selvaraj, Sarubala Malayaperumal, Malathi Kullappan, Sudarsanam Dorairaj, Jayesh R. Gujarathi, Sri Harshini Gandhamaneni and Krishna Mohan Surapaneni
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:51
    Content type: Research Published on:

  39. Colorectal cancer (CRC) is one of the most important cancers in the world, and its prevalence varies depending on the geographical area. Genetically, tumor regeneration in CRC as a multi-step process involves ...

    Authors: Hoora Naebi, Ahmadreza Bandegi, Fereshteh Talebinasab, Pirouz Samidoust, Seyedeh Elham Norollahi, Sogand Vahidi and Ali Akbar Samadani
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:57
    Content type: Research Published on:

  40. Breast cancer screening can reduce mortality and improve the quality of life in affected women. The present study aimed to determine the predictive factors of breast cancer screening in Iranian women based on ...

    Authors: Narjes Bahri, Fariba Mardani, Neda Sharifi and Sareh Dashti
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:50
    Content type: Systematic Review Published on:

  41. Ipsilateral synchronous renal and ureteric tumor is uncommon. Nephron sparing surgery is the standard for small renal masses. Ureteric tumors can be selectively managed with nephron sparing surgery, especially...

    Authors: Anandan Murugesan
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:49
    Content type: Case Reports Published on:

  42. Surgical resection is the primary treatment for advanced-stage heterotopic ossification (HO), with a high incidence of local recurrence reaching up to 50%. Postoperative radiotherapy (PORT) and indomethacin ar...

    Authors: Reham Mohamed, Asif Iqbal and Abosaleh Abosaleh Elawadi
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:48
    Content type: Research Published on:

  43. Urothelial carcinomas (UC) can be either in the upper or in the lower urinary tract or both. Urothelial bladder cancer (UBC) is more common than upper tract urothelial carcinoma (UTUC). This research was desig...

    Authors: Eman E. Dawood, Amira Awadalla, Abdelwahab Hashem, Ahmed A. Shokeir and A. F. Abdel-Aziz
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:47
    Content type: Research Published on:

  44. The reported incidence of leptomeningeal carcinomatosis is 3–8% in patients with solid tumours. More commonly, it has been described in the setting of advanced cancers of the lung, breast and malignant melanoma.

    Authors: Jhansi Pattanaik, Varshu Goel, Priyanka Sehrawat, Ruchi Rathore, Rajesh Kumar Singh, Ajay Garg and Ahitagni Biswas
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:46
    Content type: Case Reports Published on:

  45. Brain metastases (BM) are associated with dismal prognosis as they cause significant morbidity and affect the quality of life of patients. Management of BM depends on the following factors: age, patient perfor...

    Authors: Sweety Gupta, Sumit Singh, Atokali Chophy, Sharanya Nair, Rachit Ahuja, K. Kusum, Deepa Joseph, Rajnish Arora, Amit Gupta and Manoj Gupta
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:45
    Content type: Research Published on:

  46. The conventional standard treatment for ovarian cancer is not very effective, and the disease is fatal for women. Cancer Stem Cells (CSCs) that express CD44+/CD24- can contribute to chemoresistance and a poor pro...

    Authors: Unedo Hence Markus Sihombing, Andrijono Andrijono, Gatot Purwoto, Supriadi Gandamihardja, Alida R. Harahap, Primariadewi Rustamadji, Aria Kekalih, Retno Widyawati and Dzicky Rifqi Fuady
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:44
    Content type: Research Published on:

  47. EGFR mutation has not been extensively studied in thyroid cancer. This study was conducted to study spectrum of EGFR mutation in thyroid cancer in Kashmiri population for possible therapeutic purpose.

    Authors: Tariq Ahmad Mir, Ajaz Qadir, Munir Ahmad Wani and Muzafar Maqsood Wani
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:43
    Content type: Research Published on:

  48. Endometrial cancer (EC) is a common malignant tumor in women with increasing mortality. The prognosis of EC is highly heterogeneous which needs more effective biomarkers for clinical decision. Here, we reporte...

    Authors: Shiyang Li, Junan Pan, Yanyu Zhang, Yan Tang, Xiaobing Zeng, Shihai Wang, Dengxuan Wu, Yuyong Liu, Dawen Xu, Jianjun Lan and Dong Hu
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:42
    Content type: Research Published on:

  50. Urothelial carcinoma (UC) is the most common type of bladder cancer. Glucose transporter 4 (GLUT4) is one of glucose transporter proteins’ family which facilitates glucose transport inside the cells. It was fo...

    Authors: Marwa A. Abd El-Azeem, Mona A. Ali and Safinaz H. El-Shorbagy
    Citation: Journal of the Egyptian National Cancer Institute 2022 34:40
    Content type: Research Published on:
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  • ISSN: 2589-0409 (electronic)