Articles

Clinico-epidemiological profile and treatment outcomes in patients with squamous cell carcinoma of the esophagus following docetaxel-based neoadjuvant chemotherapy: experience from a cancer care center in Northeast India

Squamous cell carcinoma of the esophagus ranks as the most common cause of cancer incidence and mortality in males and the second most common in females. Surgery alone is associated with poor long-term surviva...

Authors: Partha Sarathi Roy, Gaurav Kumar, Sreya Mallik, Satya Sadhan Sarangi, Bhargab Jyoti Saikia, Munlima Hazarika and Abhijit Talukdar

Metabolic and functional imaging employment in the differentiation of brown tumors from bone metastases in a case of primary papillary thyroid cancer and parathyroid adenoma: case report

Brown tumors are benign osteoclastic bone lesions encountered in patients with hyperparathyroidism. These tumors may demonstrate aggressive, destructive features in the skeleton and imitate metastatic bone les...

Authors: Ula Al-Rasheed, Fareed Barakat and Akram Al-Ibraheem

A fare case of pancreatic metastasis from malignant melanoma mimicking pancreatitis on ¹⁸F-FDG PET/CT

Authors: Luca Filippi, Ilaria Proietti, Orazio Schillaci, Concetta Potenza and Oreste Bagni

Impact of different treatment plans on EQD₂ for intracavitary brachytherapy of cervical cancer

Cancer is one of the leading causes of death worldwide. According to GLOBOCAN estimates, there were 341,831 deaths from cervical cancer in 185 countries in 2020. The aim of this study was to compare equieffect...

Authors: Osman Vefa Gul, Gokcen Inan and Hamit Basaran

A retrospective comparison of two different immobilization systems for radiotherapy of extremity soft tissue sarcomas and its influence on CTV-PTV margin

On account of extremity wide range of movements and difficulty of reproducibility during irradiation of extremity sarcomas, assorted immobilization strategies are employed to eliminate setup errors. The study ...

Authors: Reham Mohamed, Muhammad Shuja, Asaad Al-Hazienh and Moamen Aly

Prognostic factors and outcome of pineoblastoma: 10 years single-center experience

The survival of pineoblastoma patients is low, particularly in infants and those with metastatic disease. This study aimed to analyze the prognostic factors affecting the outcome of Pineoblastoma in different ...

Authors: Ahmed Elhemaly, Mohamed S. Zaghloul, Soha Ahmed, Hala Taha, Amal Refaat, Eslam Maher, Mohamed El-Beltagy and Wael Zekry

Cutaneous involvement in diffuse large B cell lymphoma at presentation: report of two rare cases and literature review

Diffuse large B cell lymphoma (DLBCL) can occur at nodal and/or extra-nodal sites. After the gastrointestinal tract, cutaneous involvement predominates in extra-nodal DLBCL. Skin involvement at presentation ca...

Authors: Sindhu Kilaru, Soumya Surath Panda, Sourav Mishra, Debahuti Mohapatra, Manas Baisakh, Spoorthy Kolluri, Suma Devaraj, Lalatendu Moharana and Ghanashyam Biswas

Prognostic value of TERF1 expression in prostate cancer

Telomere dysfunction is one of the hallmarks of cancer and is crucial to prostate carcinogenesis. TERF1 is a gene essential to telomere maintenance, and its dysfunction has already been associates with several...

Authors: Gabriel Arantes dos Santos, Nayara Izabel Viana, Ruan Pimenta, Vanessa Ribeiro Guimarães, Juliana Alves de Camargo, Poliana Romão, Sabrina T. Reis, Katia Ramos Moreira Leite and Miguel Srougi

Massive pericardial effusion and pleural effusion: cardiac and pleural infiltration in newly diagnosed acute myeloid leukemia

Authors: Tao Ma, Hongyun Xing, Xiaofeng Zhu, Pengqiang Wu, Xiaoming Li and Yan Chen

An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Glufosfamide (β-d-glucosylisophosphoramide mustard, GLU) is an alkylating cytotoxic agent in which ifosforamide mustard (IPM) is glycosidically linked to the β-d-glucose molecule. GLU exerted its cytotoxic effect...

Authors: Doaa E. Ahmed, Fatma B. Rashidi, Heba K. Abdelhakim, Amr S. Mohamed and Hossam M. M. Arafa

Clinicopathologic features and therapy outcome in childhood Hodgkin’s lymphoma: a report from tertiary care center in Saudi Arabia

Hodgkin lymphoma (HL) is lymphoid neoplasm usually affecting lymphatic system; it accounts 3.6% of cancers in Saudi Arabia. Modern treatment protocols had shown particular success rates in overall-survival (OS...

Authors: Nawaf Alkhayat, Mohammad Alshahrani, Ghaleb Elyamany, Qanita Sedick, Walid Ibrahim, Hasna Hamzi, Amal Binhassan, Mohamed Othman, Saeed Alshieban, Mansour S. Aljabry, Shuaa Asiri, Muneerah Alzouman, Omar Alsuhaibani, Fahad Alabbas, Omar Alsharif and Yasser Elborai

Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells

Globally, head and neck cancer is the sixth most common cancer. Despite the advancement in treatment, drug resistance remains a major cause for setback. In an earlier work, the authors reported that Boswellia dal...

Authors: Akinbobola Peace Otitoju, Ishaya Yohanna Longdet, Taiwo Emmanuel Alemika and Vikram Prakash Gota

The integrative bioinformatic analysis deciphers the predicted molecular target gene and pathway from curcumin derivative CCA-1.1 against triple-negative breast cancer (TNBC)

The poor outcomes from triple-negative breast cancer (TNBC) therapy are mainly because of TNBC cells’ heterogeneity, and chemotherapy is the current approach in TNBC treatment. A previous study reported that C...

Authors: Dhania Novitasari, Riris Istighfari Jenie, Jun-ya Kato and Edy Meiyanto

Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review – a case report

Gastrointestinal complications are not uncommon in patients of Acute Leukemia. Intussusception as a complication in leukemia, although described, is exceedingly rare. Also, it is usually seen after chemotherap...

Authors: Ankur Majumder, Sunayana Misra, Vijay Kumar and Shilpa Khanna Arora

Green tea catechins in combination with irinotecan attenuates tumorigenesis and treatment-associated toxicity in an inflammation-associated colon cancer mice model

Administration of green tea (GT) catechins has been reported to ensue antitumor activity in combination with chemotherapeutic drugs against different cancer types. Irinotecan (IRN) is a highly effective chemot...

Authors: Gaurab Borah and Manuj Kumar Bharali

Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC)

P D-L1 is expressed in tumor cells and plays a crucial role in tumor immune escape. Tumor-infiltrating lymphocytes (TILs) as CD8 T cells contribute to reduced tumor growth. Few studies investigated the prognos...

Authors: Mayada Saad Farrag, Khaled Abdelwahab, Nesrine Saad Farrag, Waleed Elsayed Elrefaie and Ziad Emarah

Anti-angiogenesis in cancer therapeutics: the magic bullet

Angiogenesis is the formation of new vascular networks from preexisting ones through the migration and proliferation of differentiated endothelial cells. Available evidence suggests that while antiangiogenic t...

Authors: Ayodipupo S. Oguntade, Faez Al-Amodi, Abdullah Alrumayh, Muath Alobaida and Mwango Bwalya

Aberrant expression of multiple T cell markers on diffuse large B cell lymphoma: a case report

Aberrant T cell antigen expression has been well documented in diffuse large B cell lymphomas. However, co-expression of multiple T cell antigens including CD3, which has been considered a specific marker for ...

Authors: Anurag Mehta, Prerna Chadha, Poojan Agarwal and Sunil Pasricha

Cancer services in Sri Lanka: current status and future directions

The burden of cancer in Sri Lanka is on the rise. The overall incidence of cancer in Sri Lanka has doubled over the past 25 years with a parallel rise in cancer-related mortality. Cancer has become the second ...

Authors: Umesh Jayarajah and Anuruddha M. Abeygunasekera

Post hoc analysis of a randomized controlled trial comparing concurrent chemoradiation with cisplatin versus nimotuzumab-cisplatin, focusing on acute oral mucositis

Acute oral mucositis has been infrequently studied in the patients with head and neck squamous cell carcinoma (HNSCC) receiving once-weekly cisplatin-based chemoradiotherapy (CRT). Hence, this analysis was con...

Authors: Vanita Noronha, Vijay M. Patil, Gunjesh Kumar Singh, Amit Joshi, Nandini Menon, Sarbani Ghosh Lashkar, Vijayalakshmi Mathrudev, Kavita Nawale Satam and Kumar Prabhash

The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer

One of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation.

Authors: Elham Amjad, Solmaz Asnaashari and Babak Sokouti

Detection of activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted next-generation sequencing: a pilot study

Breast cancer (BC) is the 2^nd most prevalent malignancy worldwide and is the most prevalent cancer among Egyptian women. The number of newly described cancer-associated genes has grown exponentially since the eme...

Authors: Neemat Kassem, Hebatallah Kassem, Loay Kassem and Mohamed Hassan

Retrospective study of Dana Farber Consortium Protocol in newly diagnosed Egyptian adolescents and young adults with acute lymphoblastic leukemia: Tanta experience

Intensive acute lymphoblastic leukemia (ALL) regimens in children improve the 5-year event-free survival (EFS) to reach ~ 90%. Adolescents and young adults (AYA) have EFS (30% to 45%). Young AYA ALL patients t...

Authors: Hossam Eldin A. Elashtokhy, Heba E. Elgohary, Basant B. Eldeep, Sally M. Gaber and Tamer A. Elbedewy

Acral vascular syndrome Lennert type T cell lymphoma—a case report

Acral vascular syndrome clinically presents as digital ischemia with Raynaud’s phenomenon and erythromelalgia but can be rarely seen in the malignant condition. Patients may present pain, permanent digital bla...

Authors: Kamal Bandhu Klanidhi, S. Ashwin Monian and Avinash Chakrawarty

Steroids—has the time come to extend their use to AML?

In 2018, leukaemia accounted for 2.6% of all new cancers, it being the 13th most common cause of cancer and the 10th most common cause of cancer death. Glucocorticoids are commonly used in lymphoid leukaemia t...

Authors: Mariah Farrugia, Catriona Cutajar, Jean Calleja Agius and Pierre Schembri Wismayer

Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups

Medulloblastoma (MB) is a heterogeneous disease, displaying distinct genetic profiles with specific molecular subgroups. This study aimed to validate MB molecular subgrouping using surrogate immunohistochemist...

Authors: Asmaa Mustafa Eid and Nehal Abd El-Ghaffar Heabah

The implications of a pathological complete response of the primary tumour after neoadjuvant chemotherapy for breast cancer on axillary surgery

Management of the node-positive axilla after neoadjuvant chemotherapy is controversial. The aim of this study is to predict the group of patients who may require a less invasive approach for axillary managemen...

Authors: Mina M. G. Youssef, Ahmed A. Metwally and Tamer M. Manie

Drug delivery nanocarriers and recent advances ventured to improve therapeutic efficacy against osteosarcoma: an overview

Osteosarcoma (OS) is one of the key cancers affecting the bone tissues, primarily occurred in children and adolescence. Recently, chemotherapy followed by surgery and then post-operative adjuvant chemotherapy ...

Authors: Sujit Arun Desai, Arehalli Manjappa and Preeti Khulbe

Vaginal metastasis in solid tumours: our four cases and review of the literature

Vaginal metastasis should be kept in mind when evaluating the staging tests of all cancers, especially endometrial cancer.

Authors: Mustafa Korkmaz, Melek Karakurt Eryılmaz, Ülkü Kerimoğlu, Mustafa Karaağaç, Aykut Demirkıran, Emine Türen Demir and Mehmet Artaç

Feasibility of Monte-Carlo algorithm in comparison with collapse-cone dose calculation algorithm of a commercial treatment planning system in the presence of high-density metallic implant: a dosimetric study

The number of people with implanted hip prosthesis has grown worldwide. For radiotherapy planning of patients with hip implants, few main challenges are encountered. The aim of the present study was to evaluat...

Authors: Manindra Bhushan, Deepak Tripathi, Girigesh Yadav, Lalit Kumar, Rahul Lal Chowdhary, Anjali K. Pahuja, Tamilarasu Suresh, Sushil Kumar Shukla and Swarupa Mitra

Renal angiomyoadenomatous tumor (RAT): a rare distinct entity with diagnostic challenges—a case report

Renal angiomyoadenomatous tumor (RAT) is a recently described rare renal neoplasm with variations in the presentation, gross, and microscopic findings, and having a benign course and good prognosis. It is char...

Authors: Ankur Majumder, Ravi Hari Phulware, Arvind Ahuja, Anurag Singla and Pawan Kumar

Urinary schistosomiasis and the associated bladder cancer: update

Urinary schistosomiasis and its severe complications, mainly bladder cancer, are scarce in non-endemic areas. The deficiency in knowledge and clinical experience of schistosomiasis may lead to inadequate manag...

Authors: Mohamed S. Zaghloul, Tarek M. Zaghloul, Mai K. Bishr and Brian C. Baumann

The clinical impact of hepatitis C virus infection in Egyptian multiple myeloma patients

Multiple myeloma (MM) is a human B cell neoplasia characterized by the clonal proliferation of malignant plasma cells in the bone marrow. Worldwide, hepatitis C virus (HCV) infection is a public health problem...

Authors: Neemat M. Kassem, Hebatallah A. Kassem, Magdy Ibrahim, Hussam Zawam and Emad Hamada

Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer

Podophyllotoxin (PPT) is a naturally occurring compound obtained from the roots of Podophyllum species, indicated for a variety of malignant tumors such as breast, lung, and liver tumors. This toxic polyphenol...

Authors: Popat S. Kumbhar, Asmita M. Sakate, Onkar B. Patil, Arehalli S. Manjappa and John I. Disouza

Systemic recurrence of endometrial cancer more than 10 years after hysterectomy: a report of two cases and a brief review of the literature

Endometrial carcinoma is one of the most common female cancers in developed countries. Disease stage is associated with the risk of disease relapse after radical treatment. Typically, the risk of disease relap...

Authors: Leonardo Muratori, Paola Sperone, Gabriella Gorzegno, Anna La Salvia and Giorgio Vittorio Scagliotti

Pitfalls in scientific research: critical appraisal of articles published in one of the international journals in Egypt

To identify and report flaws of Internet-published articles in the Journal of the Egyptian National Cancer Institute (JENCI), Cairo University, through a retrospective documentary study on articles published duri...

Authors: Sarah S. Nasr, Ghada M. Sherif, Amal S. Ibrahim and Rasha M. Allam

Primary urethral small cell melanoma with neuroendocrine differentiation: a case report

Primary malignant melanoma of the female urethra is an exceedingly rare tumor. It represents 0.2% of all malignant melanomas. Divergent differentiation towards non-melanocytic lineages has not been reported in...

Authors: Tripti Nakra, Rohit Dadhwal, Rishi Nayyar, Sameer Rastogi, Aanchal Kakkar, Mehar Chand Sharma and Rajni Yadav

Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma

Glutathione can reduce the oxidative stress by converting the unstable to stable molecules and its status in hepatocellular carcinoma (HCC) is correlated with tumor growth and metastasis.

Authors: Shaimaa Gamal Hassan Elofey, Nevine F. Shafik, Noha Hassan Radwan, Osman Mohammed Mansour, Rasha Mahmoud Allam, Samia Shouman and Iman Attia AbdelGawad

S100A14 serum level and its correlation with prognostic factors in breast cancer

Breast cancer is the most commonly occurring cancer in women worldwide. S100A14 is a novel important member of S100 proteins family. Its importance is due to its role in tumorigenesis and metastasis process. I...

Authors: Noor Al-Ashkar and Almoutassem Billah Zetoune

Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed ...

Authors: Nabiha Missaoui, Ahlem Bdioui, Atika Baccouche, Oussema Belkacem, Wissem Hmida, Moncef Mokni and Sihem Hmissa

Identification of serum biomarker panel to differentiate malignant from benign thyroid nodules using multiplex bead assay

The challenging target in the workup of thyroid nodule(s) is to exclude or diagnose thyroid cancer efficiently prior to surgical intervention. The present work studied a panel of eight serum biomarkers to diff...

Authors: Ragaa Abdelkader Ramadan, Wafaa Ragab, Ramy Samir Assaad, Ahmed Elsayed Shaaban and Amira Ibrahim Fayad

Impact of DAXX and ATRX expression on telomere length and prognosis of breast cancer patients

Telomere stability is one of the hallmarks of cancer that promotes cellular longevity, the accumulation of genetic alterations, and tumorigenesis. The loss of death domain-associated protein (DAXX) and α-thala...

Authors: Marwa T. Hussien, Shimaa Shaban, Doaa F. Temerik, Shaaban R. Helal, Eman Mosad, Sahar Elgammal, Abeer Mostafa, Eman Hassan and Abeer Ibrahim

Localized Wilms’ tumor in low-middle-income countries (LMIC): how can we get better?

Wilms’ tumor (WT) represents about 6% of all childhood cancers. The overall survival markedly improved to exceed 90% in developed countries, yet some studies from developing counties still have poorer outcomes...

Authors: Hosam Y. Asfour, Sahar A. Khalil, Al-Shimaa Zakaria, El-Sayed Ashraf and Wael Zekri

Initial absolute monocyte count as an immune biomarker for clinical response in acute myeloid leukemia with monocytic differentiation

Absolute monocyte count (AMC) correlates with survival outcomes in various hematologic malignancies. However, its role in myeloid malignancies including AML needs to be highlighted. So, this prospective cohort...

Authors: Ahmed Embaby, Ayman Fathy, Mohammad Al-Akkad, Ahmad Baraka, Taiseer Ibrahim, Nahla Zidan, Mohamed Refaat and Haitham Elsheikh

Dosimetric impact of variable bladder filling on IMRT planning for locally advanced carcinoma cervix

To evaluate the dosimetric impact of variable bladder filling on target and organ at risk (OARs) in cervical cancer patients undergoing chemoradiation. Forty consecutive patients with cervical cancer underwent...

Authors: Soumya Dutta, Abhinav Dewan, Swarupa Mitra, Manoj Kumar Sharma, Sumeet Aggarwal, Soumitra Barik, M. Mahammood Suhail, Maninder Bhushan, Anurag Sharma, Inderjeet Kaur Wahi, Kiran Dobriyal and Jwala Mukhee

Metastatic colorectal carcinoma initially diagnosed by bone marrow biopsy: a case report and literature review

Colorectal carcinoma still represents a global health burden despite the advances in its management. The most common sites of distant metastasis from colorectal carcinoma are hepatic and pulmonary metastases w...

Authors: Reham Alghandour, Gehad A. Saleh, Farida Ahmed Shokeir and Mohammad Zuhdy

Application of periareolar mastopexy technique for giant phyllodes tumor resection in an adolescent female with breast asymmetry: a case report and literature review

The phyllodes tumors are rare neoplastic disease which exhibits a benign behavior in adolescents female. After resection of a large benign breast tumor, insufficient breast contour may result with nipple areol...

Authors: Mahmoud A. Hifny, Mohamed Yousef A., Asmaa Gaber R., Mohamed Abdelshafy Mohamed and Mahmoud Abdelhameid

A quasi-randomized clinical trial: virtual reality versus proprioceptive neuromuscular facilitation for postmastectomy lymphedema

Postmastectomy lymphedema can be considered the main cause of upper extremity functional impairment in patients with breast cancer. Fatigue, pain, and limited range of motion are common symptoms. If left untre...

Authors: Doaa Atef, Mohmed Maher Elkeblawy, Ashraf El-Sebaie and Walid Ahmed Ibrahim Abouelnaga

Irradiation free conditioning regimen is associated with high relapse rate in Egyptian patients with acute lymphoblastic leukemia following allogeneic hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a curative treatment for adult patients with acute lymphoblastic leukemia (ALL). Cyclophosphamide plus total body irradiation (TBI/Cy) or plus ...

Authors: Mona Mahrous Abdelaty, Amr Gawaly, Gamal M. Fathy, Ibrahim Kabbash and Atef Taha

Inflammatory myofibroblastic tumor of maxillary sinus successfully treated with radiotherapy and corticosteroid: report of a rare case

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor mainly found in lung or retroperitoneum and rarely affects head and neck region. Extensive English literature search reveals that less than fifty...

Authors: Rituparna Biswas, Anirban Halder, Mimi Gangopadhyay and Dipanwita Biswas