Table 7 Relation between combined densities of CD163 expression in both tumor nest and stroma and clinicopathologic characteristics
Total | CD163-positive TAMs | p | ||||
|---|---|---|---|---|---|---|
TNLow and TSLow A N = 17 N (%) | TNHigh and TSLow B N = 15 N (%) | TNHigh and TSHigh C N = 14 N (%) | TNLow and TSHigh D N = 14 N (%) | |||
Age (years) mean ± SD | 52.06 ± 11.53 | 46.00 ± 11.82 | 53.57 ± 5.71 | 53.43 ± 14.98 | 0.245 | |
Size | ||||||
< 5 cm | 39 | 14 (35.9) | 11 (28.3) | 7 (17.9) | 7 (17.9) | 0.136 |
≥ 5 cm | 21 | 3 (14.4) | 4 (19) | 7 (33.3) | 7 (33.3) | |
Grade | ||||||
GII | 32 | 11 (34.4) | 7 (21.9) | 3 (9.3) | 11 (34.4) | 0.014* |
GIII | 28 | 6 (21.4) | 8 (28.6) | 11 (39.3) | 3 (10.7) | |
Pairwise comparison: AB:0.476, AC:0.029*, AD: 0.456, BC:0.245, BD: 0.128, CD: 0.007* | ||||||
Nodal metastasis | ||||||
Negative | 26 | 12 (46.2) | 9 (34.6) | 2 (7.7) | 3 (11.5) | 0.002* |
Positive | 34 | 5 (14.7) | 6 (17.6) | 12 (35.3) | 11 (32.4) | |
Pairwise comparison: AB: 0.712, AC:0.003*, AD:0.011*, BC: 0.021*, BD: 0.60, CD: 1 | ||||||
Stage | ||||||
I | 3 | 3 (100) | 0 (0) | (0) | (0) | 0.010* |
II | 32 | 11 (34.4) | 11 (34.4) | 5 (15.6) | 5 (15.6) | |
III | 25 | 3 (12) | 4 (16) | 9 (36) | 9 (36) | |
Pairwise comparison: AB: 0.219, AC: 0.018*, AD: 0.018*, BC:0.126, BD: 0.126, CD: 1 | ||||||
Vascular invasion | ||||||
Negative | 22 | 10 (45.5) | 6 (27.3) | 3 (13.6) | 3 (13.6) | 0.097 |
Positive | 38 | 7 (18.5) | 9 (23.7) | 11 (28.9) | 11 (28.9) | |
ER | ||||||
Negative | 13 | 1 (7.7) | 1 (7.7) | 7 (53.8) | 4 (30.8) | 0.012* |
Positive | 47 | 16 (34) | 14 (29.8) | 7 (14.9) | 10 (21.3) | |
Pairwise comparison: AB: 1, AC: 0.011*, AD: 0.148, BC: 0.014*, BD:0.169, CD: 0.441 | ||||||
PR | ||||||
Negative | 26 | 6 (23.1) | 6 (23.1) | 7 (26.9) | 7 (26.9) | 0.779 |
Positive | 34 | 11 (32.4) | 9 (26.4) | 7 (20.6) | 7 (20.6) | |
Her2 | ||||||
Negative | 45 | 13 (28.8) | 8 (17.8) | 12 (26.7) | 12 (26.7) | 0.180 |
Positive | 15 | 4 (26.7) | 7 (46.7) | 2 (13.3) | 2 (13.3) | |
Ki-67 | ||||||
≤ 14% | 29 | 13 (44.8) | 4 (13.8) | 4 (13.8) | 8 (27.6) | 0.012* |
> 14% | 31 | 4 (12.9) | 11 (35.5) | 10 (32.3) | 6 (19.3) | |
Pairwise comparison: AB: 0.012*, AC:0.012*, AD: 0.441, BC: 1, BD: 0.139, CD: 0.252 | ||||||
Molecular subtypes | ||||||
Luminal A | 27 | 13 (48.2) | 2 (7.4) | 4 (14.8) | 8 (29.6) | <0.001* |
Luminal B | 24 | 4 (16.7) | 12 (50) | 6 (25) | 2 (8.3) | |
Triple negative | 9 | 0 (0) | 1 (11.2) | 4 (44.4) | 4 (44.4) | |
Pairwise comparison: AB: 0.002*, AC: 0.011*, AD: 0.060, BC: 0.108, BD: 0.002*, CD:0.189 | ||||||