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Table 4 Relation of molecular subgroups to clinicopathological parameters

From: Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups

  Molecular subgroups P value
  WNT (n = 4) SHH (n = 12) Non-WNT/SHH (n = 24)
Age group (years)     
 < 3 (infants) 0 (0%) 2 (16.7%) 6 (25%) MC, p = 0.031*
 3-16 (pediatric age) 3 (75%) 6 (50%) 18 (75%)
 > 16 (adults) 1 (25%) 4 (33.3%) 0 (0%)
Sex     
 Male 1 (25%) 5 (41.7%) 16 (66.7%) MC, p = 0.183
 Female 3 (75%) 7 (58.3%) 8 (33.3%)
Location of the mass     
 Midline 4 (100%) 1 (8.3%) 22 (91.7%) MC, p < 0.001*
 Lateral 0 (0%) 11 (91.7%) 2 (8.3%)
Histopathological types     
 Classic medulloblastoma 3 (75%) 0 (0%) 11 (45.8%) MC, p < 0.001*
 Desmoplastic/nodular medulloblastoma 0 (0%) 10 (83.3%) 0 (0%)
 Large cell/anaplastic medulloblastoma 1 (25%) 2 (16.7%) 13 (54.2%)
Degree of anaplasia     
 Slight anaplasia 2 (50%) 3 (25%) 2 (8.3%) MC, p = 0.255
 Moderate anaplasia 1 (25%) 5 (41.7%) 9 (37.5%)
 Severe anaplasia 1 (25%) 4 (33.3%) 13 (54.2%)
Risk stratification     
 Standard risk 4 (100%) 10 (83.3%) 4 (16.7%) MC, p < 0.001*
 High risk 0 (0%) 2 (16.7%) 20 (83.3%)
  1. MC Monte Carlo
  2. *Statistically significant at p ≤ 0.05