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Table 8 Effects of glufosfamide on ATP level in HepG2 cells

From: An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Time period Control Glufosfamide (µM)1   
10 25 50
48 h 20.9 ± 1.2 16.6a ± 0.9 13.1a ± 0.5 9.6a ± 0.4
72 h   15.3b ± 0.6 10.2*,b ± 0.4 6.9*,b ± 0.5
  1. Data represent mean ± SE (n = 4)
  2. ATP level is expressed as nmol/mg protein
  3. 1Glufosfamide was used in its IC50 value beside two of its fractions; 10 and 25 µM
  4. The number of HepG2 cells used was in the range of 5 × 105 ~ 5 × 106 cells/mL
  5. *Significantly different from the same concentration incubated with HepG2 cells for 48 h at P < 0.05, using independent Student’s t test
  6. a,bData in the same rows having the same superscript are significantly different from each other at P < 0.05 using one-way analysis of variance (ANOVA) followed by Tukey as post hoc test