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Table 9 Effects of ifosfamide on ATP level in HepG2 cells

From: An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Time period Control Ifosfamide (µM)1
25 50 100
48 h 20.9 ± 1.2 19.3 ± 0.9 15.2a ± 0.4 11.6a ± 0.5
72 h   16.2*,b ± 0.5 12.1*,b ± 0.3 8.5*,b ± 0.4
  1. Data represent mean ± SE (n = 4)
  2. ATP level is expressed as nmol/mg protein
  3. 1Ifosfamide was used in its IC50 value beside two of its fractions; 25 and 50 µM
  4. The number of HepG2 cells used was in the range of 5 × 105 ~ 5 × 106 cells/mL
  5. *Significantly different from the same concentration incubated with HepG2 cells for 48 h at P < 0.05, using independent Student’s t test
  6. a,bData in the same rows having the same superscript are significantly different from each other at P < 0.05 using one-way analysis of variance (ANOVA) followed by Tukey as post hoc test