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Journal of the Egyptian National Cancer Institute

Table 4 Summary of the association between VEGF-A +936C/T polymorphism and CRC in different genetic models and according to ethnicity

From: A microRNA binding site polymorphism in the 3′ UTR region of VEGF-A gene modifies colorectal cancer risk based on ethnicity: a meta-analysis

Models Ethnicity and quality of the study Parameters
  OR 95% CI Association p-value Heterogeneity p-value I2 Egger’s test p-value
C vs. T Overall 0.9983 [0.91–1.09] 0.97169 0.0007 0.6458 0.6927
East Asian 0.6537 [0.53–0.80] 0.00003 0.4693 0 0.0177
South Asian 1.3375 [0.84–2.11] 0.2141 NA NA NA
Caucasian 1.0563 [0.91–1.22] 0.4637 0.1745 0.3493 0.6018
Quality of the study 1.2242 [0.78–1.90] 0.3694 NA NA NA
CC vs. CT + TT Overall 1.0221 [0.92–1.13] 0.68371 0.0004 0.6591 0.6999
East Asian 0.6273 [0.49–0.78] 0.00006 0.4845 0 0.1031
South Asian 1.2901 [0.78–2.12] 0.3191 NA NA NA
Caucasian 1.0982 [0.92–1.29] 0.27 0.1489 0.3855 0.5338
Quality of the study 1.5363 [0.92–2.55] 0.0967 NA NA NA
CC + CT vs. TT Overall 0.8024 [0.58–1.10] 0.17928 0.6291 0 0.8515
East Asian 0.4813 [0.23–1.00] 0.0518 0.8723 0 0.4451
South Asian 5.6331 [0.3008; 105.4861] 0.2475 NA NA NA
Caucasian 0.8538 [0.52–1.39] 0.5264 0.3652 0.08 0.7439
Quality of the study 0.2761 [0.05–1.35] 0.1121 NA NA NA
CT vs. CC + TT Overall 0.9525 [0.85–1.06] 0.37577 0.0019 0.6143 0.7475
East Asian 1.5047 [1.19–1.90] 0.0006 0.4893 0 0.1881
South Asian 0.8515 [0.51–1.41] 0.5325 NA NA NA
Caucasian 0.8843 [0.74–1.04] 0.1603 0.1346 0.4061 0.4246
Quality of the study 0.5252 [0.30–0.89] 0.0177 NA NA NA
CC vs. CT Overall 1.0426 [0.93–1.16] 0.45 0.001 0.634 0.7373
East Asian 0.6478 [0.51–0.81] 0.0002 0.4897 0 0.1603
South Asian 1.2055 [0.72–1.99] 0.46867 NA NA NA
Caucasian 1.1245 [0.94–1.33] 0.1824 0.1323 0.4095 0.4483
Quality of the study 1.8293 [1.07–3.12] 0.0268 NA NA NA
  1. OR odds ratio, CI confidence interval, I2 I square.*Italicized values are statistically significant
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