Table 4 Comparison between patients with and without malnutrition according to commonly observed toxicities of the HDMTX cycles (N = 120)
Cycles in patients without malnutrition (N= 88) | Cycles in patients with malnutrition (N = 32) | p | |
|---|---|---|---|
N (%) | |||
Hematological toxicities | |||
Neutropenia | |||
No | 20 (22.7) | 8 (25.0) | “χ2 test” p=0.795 |
Yes | 68 (77.3) | 24 (75.0) | |
G3–4 | 49 (55.7) | 21 (65.6) | “χ2 test” p=0.329 |
Anemia | |||
No | 18 (20.5) | 10 (31.3) | “χ2 test” p=0.216 |
Yes | 70 (79.5) | 22 (68.8) | |
G3–4 | 28 (31.8) | 7 (21.9) | “χ2 test” p=0.289 |
Thrombocytopenia | |||
No | 61 (69.3) | 22 (68.8) | “χ2 test” p=0.952 |
Yes | 27 (30.7) | 10 (31.3) | |
G3–4 | 15 (17.0) | 4 (12.5) | “χ2 test” p=0.546 |
Febrile neutropeniaa | |||
No | 66 (75.0) | 23 (71.9) | “χ2 test” p=0.729 |
Yes | 22 (25.0) | 9 (28.1) | |
Hepatic toxicity | |||
Increased ALT | |||
No | 66 (75.0) | 20 (62.5) | “χ2 test” p=0.179 |
Yes | 22 (25.0) | 12 (37.5) | |
G3–4 | 5 (5.7%) | 1 (3.1%) | FEp=1.000 |
Increased AST | |||
No | 68 (77.3) | 19 (59.4) | “χ2test”p=0.052 |
Yes | 20 (22.7) | 13 (40.6) | |
G3–4 | 3 (3.4%) | 1 (3.1%) | FEp=1.000 |
Gastrointestinal toxicity | |||
Oral mucositis | |||
No | 59 (67.0) | 17 (53.1) | “χ2 test” p=0.162 |
Yes | 29 (33.0) | 15 (46.9) | |
G3–4 | 14 (15.9%) | 6 (18.8%) | “χ2 test” p=0.783 |
Nephrotoxicity | |||
Increased creatinine | |||
No | 60 (68.2) | 20 (62.5) | “χ2 test” p=0.559 |
Yes | 28 (31.8) | 12 (37.5) | |
G3–4 | 1 (1.1%) | 1 (3.1%) | FEp=0.464 |