Fig. 4
From: Potential roles of claudin-3 and claudin-4 in ovarian cancer management
Extracellular loops represent binding sites for anti-CLDN3 antibodies, e.g., IgG1 [30] and CPE [32] (left). When CPE binds to CLDN3/4, a hexameric pore is made, compromising the cell membrane integrity. This leads to calcium ion influx and therefore cell death. The CPE-claudin complex may also incorporate occludin, thereby further breaking the TJ [32]. CPE also has been found to internalise claudins [35], further increasing the membrane’s permeability