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Table 1 Baseline profile of patients with CD20-positive HAL presenting to King Edward VIII Hospital from 2006 to 2018

From: Patient characteristics and outcome of CD20-positive HIV-associated lymphoma: a single-center KwaZulu-Natal, South African hospital 12-year retrospective review

 

Total

n = 102 (%)

CHOP

n = 50 (%)

R-CHOP

n = 52 (%)

p value (CHOP vs R-CHOP)

Histology

   

0.540

 DLBCL

70 (70%)

35 (70%)

35 (67%)

 HGBCL

31 (61%)

14 (28%)

17 (33%)

 Other

1 (2%)

1 (2%)

0

Median age in years (IQR)

39 (12)

38 (9)

39 (12)

0.525

Female

55 (54%)

31 (62%)

24 (46%)

0.108

ECOG ≥ 2

88 (86%)

44 (88%)

44 (85%)

0.618

Median CD4 in cells/μL (IQR)

196 (209)

143 (175)

228 (211)

0.166

CD4 ≤ 200 cells/μL

53 (52%)

30 (60%)

23 (44%)

0.210

CD4 > 200 cells/μL

49 (48%)

20 (40%)

29 (56%)

ART at lymphoma diagnosis

46 (45%)

18 (36%)

28 (54%)

0.021

Extra nodal disease

72 (71%)

36 (72%)

36 (69%)

0.711

B symptoms

32 (31%)

17 (34%)

15 (29%)

0.437

Bulky diseasea

36 (35%)

18 (36%)

18 (35%)

0.778

Stage III/IV disease

46 (45%)

21 (42%)

25 (48%)

0.180

IPI score

   

0.398

 1 (low risk)

17 (17%)

9 (18%)

8 (15%)

 2 (low intermediate)

31 (30%)

18 (36%)

13 (25%)

 3 (high intermediate)

23 (23%)

11 (22%)

12 (23%)

 4–5 (high risk)

30 (29%)

12 (24%)

19 (37%)

  1. HAL HIV-associated lymphoma, DLBCL diffuse large B cell lymphoma, HGBCL high-grade B cell lymphoma, ECOG Eastern Cooperative Oncology Group, ART antiretroviral treatment, IPI International Prognostic Index
  2. aBulky disease defined as tumor measuring ≥10 cm