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Table 3 Comparison of genes expression between UTUC and UBC

From: Evaluation of molecular signatures in the urinary bladder and upper tract urothelial carcinomas: a prospective controlled clinical study

 

UTUC

Noncancerous upper tract

UBC

Noncancerous bladder

p-value

MAPK/ERK pathway

 EGFR

5.28 ± 2.69

1.05 ± 0.9

2.85 ± 0.9

1.05 ± 0.14

< 0.001a, b, c

 ELK-1

5.00 ± 0.97

0.97 ± 0.08

3.15 ± 0.72

1.07 ± 0.18

< 0.001a, b, c

 c-fos

5.11 ± 1.85

1 ± 0.07

3.12 ± 0.77

1.06 ± 0.16

< 0.001a, b, c

Cell cycle regulators

 Survivin

12.75 ± 6.28

0.98 ± 0.1

5.73 ± 1.32

1.02 ± 0.15

< 0.001a, b, c

 TP53

5.75 ± 1.21

0.96 ± 0.07

3.21 ± 0.8

1.03 ± 0.97

< 0.001a, b, c

 RB1

0.37 ± 0.37

1.03 ± 0.08

0.50 ± 0.25

1.01 ± 0.09

< 0.001a, b

0.133c

Oncogenic genes

 FGFR3

5.12 ± 2.82

1 ± 0.07

2.88 ± 0.60

1.06 ± 0.16

< 0.001a, b, c

 hTERT

3.56 ± 1.3

1.02 ± 0.09

3.28 ± 0.97

1.02 ± 0.1

< 0.001a, b

0.395c

  1. ap-value between UTUC and noncancerous upper tract
  2. bp-value between UBC and noncancerous bladder
  3. cp-value between UTUC and UBC