Skip to main content
Journal of the Egyptian National Cancer Institute
Fig. 1 | Journal of the Egyptian National Cancer Institute

Fig. 1

From: In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells

Fig. 1

Synergism cytotoxicity of Hsd and DOX on 4T1 breast cancer cells. 4T1 cells were treated individually or in combination with Hsd plus DOX at various concentrations for 24 h, and the viability of cells was evaluated using MTT assay. Percentage of cell viability under A Hsd and B DOX, C combination of Hsd-DOX treatment for 24 h. Cell viability profiles were expressed as mean ± SD from three independent experiments. D The combination index (CI) value of various combination ratios. CI value below and above CI = 1 will indicate synergism and antagonism, respectively. E Dose–effect curves of Hsd, DOX, and its combination. Dose–effect curves were generated from the CompuSyn calculation, and the values are the mean of three experiments. F Combination index plot among 6 combinations, all of the data were on the synergistic side (CI < 1). *p < 0.001 (post-hoc LSD test between each group) was considered statistically significant

Back to article page