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Journal of the Egyptian National Cancer Institute
Fig. 3 | Journal of the Egyptian National Cancer Institute

Fig. 3

From: In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells

Fig. 3

Effect of Hsd, DOX, and combination treatment on the migration ability of 4T1 breast cancer cells. A After treatment, the formation of lamellipodia was observed under inverted microscopy (× 100 magnification). The red arrows that there are morphological differences. B Cell migration was assessed via scratch wound healing assay. C The migration abilities were quantified by counting the area of closure using ImageJ, and the percentage of the treated group compared to the untreated group is presented as the mean ± SD of the triplicate independent experiment. D The expression level of pro MMP-9 protein was measured by ELISA. The quantitative data were shown as the mean ± SD of the triplicate independent experiment. *p < 0.001 (post-hoc LSD test between each group) was considered statistically significant

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