Journal of the Egyptian National Cancer Institute

Table 4 The diagnostic validity and the optimal cut-off values of AFP and HCC marker combination

From: Noninvasive identification of molecular biomarkers of hepatocellular carcinoma in HCV-Egyptian patients

Variable	Cutoff	Sens. %	Spec.%	AUC	SE	95% (CI)	p-value
AFP	7.55	78.6%	72.7%	0.799	0.08	0.64–0.95	0.003
AFP & CK-1	–	92.9%	72.7%	0.83	0.07	0.69–0.97	0.001
AFP & GPC-3	–	71.4%	63.6%	0.77	0.09	0.60–0.94	0.008
AFP & ADAM-8	–	71.4%	77.3%	0.81	0.07	0.67–0.95	0.002
AFP & HGF	–	64.3%	63.6%	0.76	0.08	0.60–0.92	0.009
AFP & MDK	–	71.4%	81.8%	0.80	0.08	0.64–0.96	0.003

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