Table 5 The diagnostic validity and the optimal cut-off values of different HCC markers combination
Variables | Sensitivity | Specificity | AUC | SE | 95% CI | p-value |
|---|---|---|---|---|---|---|
AFP, CK-1, & GPC-3 | 86.4% | 71.4% | 0.85 | 0.07 | 0.72–0.97 | 0.001 |
AFP, CK-1, & ADAM8 | 77.3% | 64.3% | 0.83 | 0.07 | 0.69–0.96 | 0.001 |
AFP, CK-1, & HGF | 77.3% | 64.3% | 0.80 | 0.07 | 0.66–0.95 | 0.003 |
AFP, CK-1, & DMK | 81.8% | 64.3% | 0.83 | 0.07 | 0.69–0.97 | 0.001 |
AFP, GPC-3, & ADAM8 | 86.4% | 64.3% | 0.79 | 0.08 | 0.63–0.96 | 0.003 |
AFP, GPC3, & HGF | 86.4% | 71.4% | 0.82 | 0.09 | 0.65–0.98 | 0.002 |
AFP, GPC3, & MDK | 81.8% | 78.6% | 0.83 | 0.08 | 0.68–0.99 | 0.001 |
AFP, ADAM8, & HGF | 81.8% | 78.6% | 0.81 | 0.08 | 0.65–0.96 | 0.002 |
AFP, ADAM8, & MDK | 77.3% | 71.4% | 0.83 | 0.07 | 0.69–0.96 | 0.001 |
AFP, HGF, & MDK | 81.8% | 71.4% | 0.79 | 0.09 | 0.62–0.95 | 0.004 |