Table 2 The association of PD-L1 expression with clinicopathological features
Variables | PD-L1 low expression N = 27(27%) | PD-L1 High expression N = 73(73%) | Test of significance | P value |
|---|---|---|---|---|
Gender | ||||
Male | 14 (51.9%) | 35 (47.9%) | 0.12 | 0.73 |
Female | 13 (48.1%) | 38 (52.1%) | ||
Age/years | ||||
≤ 60 | 17 (63%) | 35 (47.9%) | 1.78 | 0.18 |
> 60 | 10 (37%) | 38 (52.1%) | ||
HCV seropositivity | ||||
Yes | 13 (48.1%) | 20 (27.4%) | 3.8 | 0.05 |
No | 14 (51.9%) | 53 (72.9%) | ||
Serum LDH | ||||
Normal | 6 (22.2%) | 15 (20.5%) | 0.03 | 0.9 |
Elevated | 21(77.8%) | 58 (79.5%) | ||
B symptoms | ||||
No | 17 (63%) | 39 (53.4% | 0.73 | 0.39 |
Yes | 10 (37%) | 34 (46.6%) | ||
Involved sites | ||||
Nodal | 18 (66.7%) | 56 (76.7%) | 1.03 | 0.3 |
Extra-nodal | 9 (33.3%) | 17 (23.3%) | ||
BM infiltration (N = 93) | ||||
No | 15 (75%) | 58 (79.5%) | 0.18 | 0.76 |
Yes | 5 (25%) | 15 (20.5%) | ||
Ann Arbor stage | ||||
I and II | 8 (29.6%) | 7 (9.6%) | 6.2 | 0.01* |
III and IV | 19 (70.4%) | 66 (90.4%) | ||
IPI risk | ||||
Low and low intermediate | 18 (66.7%) | 29 (39.7%) | 5.74 | 0.017* |
High intermediate and high | 9 (33.3%) | 44 (60.3%) | ||
Histological type | ||||
Centroblastic | 21 (77.8%) | 51 (69.9%) | 4.17 | 0.124 |
Immunoblastic | 2 (7.4%) | 17 (23.3%) | ||
Anaplastic | 4 (14.8%) | 5 (6.8%) | ||
Hans classification | ||||
GC | 7 (25.9%) | 15 (20.5%) | 0.33 | 0.56 |
Non-GC | 20 (74.1%) | 58 (79.5%) | ||
P53 expression (N = 85) | ||||
No over expression | 17 (81%) | 49 (76.6%) | 0.191 | 0.77 |
Over expression | 4 (19%) | 15 (23.4%) | ||
Double expresser | ||||
No | 23 (85.2%) | 49 (67.1%) | 3.19 | 0.07 |
Yes | 4 (14.8%) | 24 (32.9%) | ||
Triple expresser | ||||
No | 26 (96.3%) | 66 (90.4%) | 0.9 | 0.67 |
Yes | 1 (3.7%) | 7 (9.6%) | ||
Treatment response | ||||
CR | 18 (66.7%) | 24 (32.9%) | 14.9 | 0.002* |
PR | 3 (11.1%) | 8 (11%) | ||
SD | 2 (7.4%) | 1 (1.4%) | ||
PD | 4 (14.8) | 40 (54.8%) | ||
Relapse after CR | ||||
No | 16 (88.9%) | 12 (50%) | 7 | 0.01* |
Yes | 2 (11.1%) | 12 (50%) | ||