Table 1 Candidate gene associated with thyroid carcinoma

1

BAX

BCL-2 associated X

19q13.11

7

248 G > A

P53 regulates apoptosis mediated by P53 and necessitates the expression of this gene

[52]

2

XRCC1

X-ray repair cross-complementing group 1

19q13.31

17

rs25487, rs25489

rs1799782

This enzyme may control Meiogenesis and recombination within germ cells

[53]

3

XRCC3

X-ray repair cross-complementing group 3

14q32.3

11

rs861539

This gene has been associated with cancer in patients who are radiosensitive and nonradiosensitive

[54]

4

XPO5

Exportin 5

6p21.2

33

rs11077

An essential transporter of small RNAs and double-stranded RNAs, Karyopherin is the protein encoded by this gene

[55]

5

IL-10

Interleukin 10

1q31-32

7

IL-10–1082 G allele

Th1 cytokines, MHC class II Ags, and macrophage stimulation molecules are down-regulated by this substance. It also promotes antibody survival, proliferation, and production in B cells

[56]

6

BRAF

B-Raf Proto oncogene

7q34

24

–

It is a protein kinase that transduces mitogenic signals from the membrane to the nucleus of cells

[57]

7

RET

Ret Proto Oncogene

10q11.21

20

–

When bound to ligands from the glial cell-derived neurotrophic factor family, this receptor tyrosine-protein kinase facilitates the growth of glial cells, cell navigation, cell migration, and cell differentiation

[58]

8

K-RAS

K-RAS Proto Oncogene

12p12.1

7

–

Regulates cell proliferation by playing an important role

[59, 60]