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Table 2 Treatment employed in 135 metaplastic breast cancer patients

From: The conundrum of metaplastic breast cancer: a single Egyptian institution retrospective 10-year experience (2011–2020)

Treatment modality

n (%)

Surgery type

 MRM

80 (59.3)

 BCS

39 (28.9)

 Palliative mastectomy

6 (4.4)

 No surgery

10 (7.4)

NACT

 Yes

41 (30.4)

 No

94 (69.8)

aNACT type (n = 41)

 Comb. anthracycline & taxanes

27 (65.0)

 Anthracycline only

11(26.8)

 Platinum-containing regimen

4 (9.7)

 Others

1 (2.4)

Pathologic Response to NACT(n = 41)

 RCB-0

3 (7.3)

 RCB-I

3 (7.3)

 RCB-II

14 (34.1)

 RCB-III

20 (48.9)

 Unknown

1 (2.4)

ACT

 Yes

80 (59.3)

 No

55 (40.7)

ACT type (n = 80)

 Comb. anthracycline and taxanes

40 (50.0)

 Anthracycline only

20 (25.0)

 Taxanes only

14 (17.5)

 Capecitabine

5 (6.25)

 Others

1 (1.25)

Adjuvant trastuzumab for HER2+ cases (n = 19)

 Yes

14 (73.7)

 No

5 (26.3)

Adjuvant hormonal for luminal cases (n = 32)

 Yes

30 (93.7)

 No

2 (6.3)

Adjuvant hormonal type (n = 30)

 Tam

19 (63.3)

 AI

9 (30)

Tam followed by AI

2 (6.7)

Adjuvant radiation therapy (n = 119)

 Yes

94 (79)

 No

25 (21)

  1. aTwo patients received combination of anthracyclines, taxanes, and platinum, ACT adjuvant chemotherapy, AI aromatase inhibitor, BCS breast-conserving surgery, Comb. combination, MRM modified radical mastectomy, n number, NACT neoadjuvant chemotherapy, RCB residual cancer burden, Tam tamoxifen