Table 3 Multivariable logistic regression analysis for predictors of immunohistochemical expression of P53
P53 expression | Univariate logistic regression analysis | Multivariable logistic regression analysis | ||
|---|---|---|---|---|
Variables | Positive | Negative | UOR (95% CI), P | AOR (95% CI), P |
Age (years) | ||||
≤ 4 | 1 | 48 | 1.00 | 1.00 |
> 4 | 6 | 28 | 3.47 (0.74–0.91), 0.041 | 1.39 (0.58–6.12), 0.703 |
Sex | ||||
Male | 3 | 28 | 1.13 (0.65–3.43), 0.872 | |
Female | 4 | 48 | 1.00 | - |
Lag period (months) | ||||
≤ 3 | 4 | 23 | 1.00 | - |
> 3 | 3 | 53 | 0.46 (0.85–13.07), 0.704 | |
SIOP clinical stage | ||||
I–II | 3 | 45 | 1.00 | - |
III–V | 4 | 31 | 1.34 (0.29–4.95), 0.072 | |
Tumor size (cm) | ||||
≤ 4 | 3 | 17 | 1.00 | - |
> 4 | 4 | 59 | 1.27 (0.68–5.08), 0.493 | |
Risk stratification | ||||
Low | 1 | 35 | 1.00 | 1.00 |
Intermediate | 1 | 28 | 0.31 (0.78–13.07), 0.511 | - |
High | 5 | 13 | 1.94 (3.60–11.24), 0.001 | 3.42 (7.91–12.55), 0.037 |
Morphologic pattern | ||||
Other patterns | 0 | 6 | 1.00 | 1.00 |
Blastemal | 3 | 6 | 1.39 (2.55–21.90), 0.044 | 1.1 (0.674–5.12), 0.201 |
Triphasic | 3 | 65 | 1.72 (7.41–15.06), 0.023 | 1.33 (0.56–5.89), 0.812 |
Presence of anaplasia | ||||
Yes | 5 | 1 | 2.03 (4.05–9.69), 0.025 | 1.41 (13.85–4.46), 0.001 |
No | 2 | 75 | 1.00 | 1.00 |