Table 2 Relation between both S100A4 and GPC3 and other variables
From: Prognostic value of S100A4 and Glypican-3 in hepatocellular carcinoma in cirrhotic HCV patients
Variables | S100A4 | Glypican 3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Positive (n = 15) | Negative (n = 55) | χ2 | p-value | Positive (n = 55) | Negative (n = 15) | χ2 | p-value | |||||
No. | % | No. | % | No. | % | No. | % | |||||
Age | ||||||||||||
 ≤ 60 y | 6 | 40.0 | 19 | 34.5 | 0.610 | 0.737 | 19 | 34.5 | 6 | 40.0 | 2.468 | 0.291 |
 > 60–70 y | 6 | 40.0 | 28 | 50.9 | 29 | 52.7 | 5 | 33.3 | ||||
 > 70 y | 3 | 20.0 | 8 | 14.5 | 7 | 12.7 | 4 | 26.7 | ||||
Mean ± SD | 61.46 ± 9.71 | 63.45±7.74 | t = 0.833 | 0.408 | 62.92 ± 6.92 | 63.40 ± 11.99 | t= 0.197 | 0.844 | ||||
Sex | ||||||||||||
 Male | 14 | 93.3 | 42 | 76.4 | 2.121 | 0.145 | 42 | 76.4 | 14 | 93.3 | 2.121 | 0 .145 |
 Female | 1 | 6.7 | 13 | 23.6 | 13 | 23.6 | 1 | 6.7 | ||||
Decompensation | ||||||||||||
 Yes | 4 | 26.7 | 16 | 29.1 | 0.034 | 0.854 | 18 | 32.7 | 2 | 13.3 | 2.172 | 0.141 |
 No | 11 | 73.3 | 39 | 70.9 | 37 | 67.3 | 13 | 86.7 | ||||
Overall survival | 9 (1–40) | 6 (1–40) | Z = 0.804 | 0.421 | 5.5 (1–40) | 8.5 (2–40) | Z = 1.222 | 0.222 | ||||
Local recurrence | ||||||||||||
 Yes | 2 | 13.3 | 15 | 27.3 | 1.245 | 0.264 | 14 | 25.5 | 3 | 20.0 | 0.191 | 0.662 |
 No | 13 | 86.7 | 40 | 72.7 | 41 | 74.5 | 12 | 80.0 | ||||
The onset of local recurrence after resection | 20.5 (5–36) | 3 (1–32) | Z = 1.372 | 0.235 | 2.5 (1–18) | 32 (9–36) | Z = 2.32 | 0.02* | ||||
Metastasis | ||||||||||||
 Yes | 4 | 26.7 | 2 | 3.6 | 7.977 | 0.005* | 3 | 5.5 | 3 | 20.0 | FET | 0.074 |
 No | 11 | 73.3 | 53 | 96.4 | 52 | 94.5 | 12 | 80.0 | ||||
Necrosis | ||||||||||||
 Yes | 10 | 66.7 | 19 | 34.5 | 5.011 | 0.025* | 21 | 38.2 | 8 | 53.3 | 1.115 | 0.291 |
 No | 5 | 33.3 | 36 | 65.5 | 34 | 61.8 | 7 | 46.7 | ||||
Microscopic vascular emboli | ||||||||||||
Yes | 9 | 60.0 | 17 | 30.9 | 4.272 | 0.039* | 19 | 34.5 | 7 | 46.7 | 0.742 | 0.389 |
No | 6 | 40.0 | 38 | 69.1 | 36 | 65.5 | 8 | 53.3 | ||||
Grading | ||||||||||||
 1 | 5 | 33.3 | 32 | 58.2 | 8.523 | 0.014* | 29 | 52.7 | 8 | 53.3 | 0.784 | 0.676 |
 2 | 3 | 20.0 | 16 | 29.1 | 16 | 29.1 | 3 | 20.0 | ||||
 3 | 7 | 46.7 | 7 | 12.7 | 10 | 18.2 | 4 | 26.7 | ||||
Size | 7.38 ± 4.28 | 6.13 ± 2.25 | t = 1.485 | 0.143 | 6.21 ± 2.68 | 7.15 ± 3.33 | t = 1.062 | 0.292 | ||||
AFP | 625 (15–2000) | 27 (2.2–2000) | Z = 2.852 | 0.004* | 45 (2.2–2000) | 10 (2.2–1283) | Z = 2.056 | 0.04* | ||||
AST | 65 (24–104) | 72 (20–190) | Z = 0.791 | 0.429 | 71.50 (20–190) | 65 (20–119) | Z = 0.677 | 0.499 | ||||
ALT | 42.5 (21–94) | 55 (20–200) | Z = 1.246 | 0.213 | 49.5 (21–200) | 54 (20–130) | Z = 0.662 | 0.508 | ||||