Table 2 Substitutions detected in exon 11 of the KIT gene in Syrian GIST patients and in silico prediction of their effect on protein structure and function

g.74423A > G

g.74424A > G

c.1649A > G

c.1650A > G

p.(Lys550Arg)

12

Deleterious (0)

Probably damaging (0.996)

Cancer promoting (− 6.07)

Disease causing (0.999)^f

g.74431T > C^a

c.1657 T > C

p.(Tyr553His)

1

Deleterious (0)

Probably damaging (1)

Cancer promoting (− 6.63)

Disease causing (0.999)

g.74437G > A

c.1663G > A

p.(Val555Ile)

1

Tolerated (0.67)

Benign (0.039)

Cancer promoting (− 5.68)

Disease causing (0.999)

g.74443T > G

c.1669T > G

p.(Trp557Gly)

1

Deleterious (0)

Probably damaging (1)

Cancer promoting (− 6.26)

Disease causing (0.999)

g.74455G > A

c.1681G > A

p.(Glu561Lys)

1

Deleterious (0)

Possibly damaging (0.875)

Cancer promoting (− 6.39)

Disease causing (0.999)

g.74468G > A

c.1694G > A

p.(Gly565Glu)

1

Deleterious (0)

Probably damaging (1)

Cancer promoting (− 7.20)

Disease causing (0.999)

g.74501T > C

c.1727T > C

p.(Leu576Pro)

1

Deleterious (0)

Possibly damaging (0.627)

Cancer promoting (− 6.92)

Disease causing (0.999)

g.74515A > G^a

c.1741 A > G

p.(Lys581Glu)

1

Deleterious (0.01)

Possibly damaging (0.811)

Cancer promoting (− 6.29)

Disease causing (0.999)

g.74531G > A

c.1757G > A

p.(Arg586Lys)

1

Deleterious (0)

Possibly damaging (0.88)

Passenger^e (− 1.74)

Disease causing (0.999)