Fig. 6
From: CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis
CircMCTP2 regulated the growth and metastasis of bladder cancer cells potentially via the miR-99a-5p/FZD8/Wnt-b-catenin axis. A The levels of both b-catenin and cyclin D1 were downregulated by the transfection with miR-99a-5p, which was abrogated by the treatment with oe-FZD8. B-F The inhibitory effects on the growth and metastasis of bladder cancer cells induced by sh-circMCTP2 were remarkably abolished by the treatment with GSK-3b inhibitor. G and H The growth of tumor was remarkably slowed in mice of sh-circMCTP2 group compared to sh-NC controls.*P < 0.05