Table 2 Distribution of genotypes and allelic frequencies of the NME1 rs34214448 and rs2302254 and DCC rs2229080 and rs714 variants in CRC and control group
Genotype | CRC group n = 232 (%) | Control group n = 232 (%) | OR (95% CI) | P value |
|---|---|---|---|---|
NME1 (rs34214448) G > T | ||||
G/G | 51 (21.98) | 99 (42.67) | 1.00 (Reference) | |
G/T | 144 (62.07) | 104 (44.83) | 2.68 (1.76- 4.09) | 0.001 |
T/T | 37 (15.95) | 29 (12.50) | 2.47 (1.37- 4.47) | 0.001 |
G/T + T/T vs. G/G | 181 (78.02) | 170 (57.33) | 2.06 (1.38 – 3.07) | 0.001 |
Allele | ||||
G | 246 (53.02) | 302(65.09) | 1.00 (Reference) | |
T | 218 (46.98) | 162(34.91) | 1.65 (1.26 – 2.151) | 0.001 |
NME1 (rs2302254) C > T | ||||
C/C | 54 (23.28) | 65 (28.02) | 1.00 (Reference) | |
C/T | 124 (53.45) | 125 (53.88) | 1.19 (0.77 – 1.85) | 0.495 |
T/T | 54 (23.28) | 42 (18.10) | 1.54 (0.90 – 2.65) | 0.147 |
C/T + T/T vs. C/C | 178 (76.72) | 167 (71.98) | 1.28 (0.82 – 1.99) | 0.287 |
Allele | ||||
C | 232 (50.0) | 255 (54.96) | 1.00 (Reference) | |
T | 232 (50.0) | 209 (45.04) | 1.22 (0.94 – 1.57) | 0.148 |
DCC (rs2229080) G < C | ||||
G/G | 48 (20.69) | 78 (33.62) | 1.00 (Reference) | |
G/C | 128 (55.17) | 104 (44.83) | 2.00 (1.28 – 3.11) | 0.002 |
C/C | 56 (24.14) | 50 (21.55) | 1.82 (1.07 – 3.07) | 0.034 |
G/C + C/C vs. G/G | 184 (79.31) | 154 (66.38) | 1.94 (1.27 – 3.02) | 0.002 |
Allele | ||||
G | 224 (48.28) | 260 (56.03) | 1.00 (Reference) | |
C | 240 (51.72) | 204 (43.97) | 1.36 (1.05 – 1.76) | 0.021 |
DCC (rs714) A > G | ||||
A/A | 45 (19.40) | 57 (24.57) | 1.00 (Reference) | |
A/G | 130 (56.03) | 108 (46.55) | 1.52 (0.95—2.43) | 0.097 |
G/G | 57 (24.57) | 67 (28.88) | 1.07 (0.63—1.82) | 0.885 |
A/G + G/G vs. A/A | 187 (80.60) | 175 (75.43) | 1.35 (0.87 – 2.10) | 0.217 |
Allele | ||||
A | 220 (47.41) | 222 (47.41) | 1.00 (Reference) | |
G | 244 (52.59) | 242 (52.59) | 1.01 (0.78—1.31) | 0.947 |